Transmission Electron Microscopy For Biology and Biological Process Research Using the Tecnai G² Spirit (Bio)TWIN from FEI Company


Fundamental research within the scope of cell biology, structural biology, soft matter and (bio)-nanotechnology is increasingly focusing on understanding interactive biological processes, pathways and structures at the macromolecular level.

Transmission electron microcopy (TEM) is of paramount importance to obtain high magnification and high resolution 2D and 3D information of cells and organelles or even smaller cell constituents. A prerequisite for optimal 2D and 3D-tomographic imaging is a high level of microscope automation and intelligence. The Tecnai G² Spirit builds on more than 50 years experience in Life Science and combines modern day technology with the stringent demands of an innovative scientific community.

Key Benefits

  • High contrast, high resolution for 20 -120 kV operation
  • Optimized for 2D & 3D imaging of cells, cell organelles and soft matter
  • High level of automation: AutoGun and AutoAdjust
  • Smart Tracking Position System (STPS)
  • Liquid nitrogen temperature observation
  • Technology for sharp imaging of thicker samples


The easy-to-use Tecnai G² Spirit is designed to ensure high-quality images and facilitate the work of the microscope user. The Tecnai G² Spirit has a high level of automation without limiting full user control. The microscope has embedded automation such as automated tuning of the gun or illumination, and automated (or manual) alignment, saturation and conditioning of the electron source. Automated tuning for focus and astigmatism is also available. Automation functions are fast and convenient, lowering the threshold for new users, and helping to secure quality results. Tecnai G² Spirit is ready for new applications like 3D-imaging using tomography (with Xplore3D) and/or cryo-electron microscopy.

In the world of Life Sciences, developments occur at a high pace. The Spirit’s design philosophy ensures applications flexibility for today and tomorrow, making it easy to add new applications and upgrade functionality. FEI Company collaborates closely with the life sciences community to better understand its needs and to co-develop dedicated tools to help illuminate complex cellular processes, functions, and relationships.

Tecnai G² Spirit will help build a detailed understanding of world of decreasing dimensions: today and in the future.

Source: FEI Company
For more information on this source please visit FEI Company

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