Computer control of scientific instrumentation can be difficult and time consuming. Mad City Labs’ new USB interface brings true “Plug & Play” ease of use into the specialized world of nanopositioning. For several years, the installation of common computer add-ons such as hard disk drives has benefited from USB standardization. Often, scientific instrumentation has lagged in this trend, forcing users to purchase older, slower interfaces such as RS-232, or GPIB which predate today’s high speed PC designs. By incorporating the ubiquitous USB interface into the Nano-DriveTM controllers, Mad City Labs has simplified system integration while also boosting data transfer rates into the company’s high speed nanopositioning stages. Compatible with common waveform generation software such as National Instrument’s LabVIEW, the Nano-DriveTM with USB comes with example Virtual Instruments (VI’s) and a software library. Mad City Labs designs and builds nanopositioning stages and controllers which allow sub-nanometer motion in up to five axes. Applications for nanopositioning include optical and electron microscopy, lithography, micro-electro-mechanical systems (MEMS), single molecule spectroscopy, optical scanning, and many others in the specialized areas of nanotechnology.