Nanograde is the leading supplier of customized nanoparticles. Nanograde's technology allows the fine-tuning of certain properties into polymer additives. Different leaders-in-the-field entrusted Nanograde with the development of tomorrow's material solutions.
Nanograde’s amorphous calcium phosphate nanoparticles (a-TCP, see Fig. 1) have proven to be highly effective in triggering formation of new bone (deposition of hydroxyapatite (HAp)) when applied in implant materials or in biomedical coatings.For bone reconstruction a-TCP nanoparticles can be used in biodegradable polymer fibers resulting in a simple application form for the surgeon and a rapid transformation of the implant into new bone. Fig. 2 shows a microscope image of a single biodegradable fiber after 48 h in contact with human body fluid. The thick layer on the surface of the fiber is newly formed bone material.
A-TCP nanoparticles and other biomedical and degradable nanoparticles are commercially available at Switzerland based Nanograde Llc. In addition to highly pure a-TCP nanoparticles, the composition can be altered with additional doping elements. Nanograde’s strong technology and know how allows customization of nanoparticle compositions and dispersions.
Figure 1. TEM picture of amorphous calcium phosphate nanoparticles.
Figure 2. Newly formed bone on PLGA fibers with a-TCP nanoparticles.
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