Improved Degradation of
Nanograde is the leading supplier of customized
nanoparticles. Nanograde's technology
allows the fine-tuning of certain properties into polymer additives. Different
leaders-in-the-field entrusted Nanograde
with the development of tomorrow's material solutions.
Biopolymers may degrade over time. In certain cases it is desired to have
shorter degradation times which are impossible to achieve by pure biopolymers.
An approach chosen by Nanograde Llc. to increase degradability kinetics is the incorporation of a-TCP
nanoparticles in such polymers (see Fig. 2).
nanoparticles and other degradable
nanoparticles are commercially available at Switzerland based Nanograde
Llc. In addition to highly pure a-TCP
nanoparticles, the composition can be altered
with additional doping elements. Nanograde’s
strong technology and knowhow allows customization of nanoparticle compositions and
Figure 1. TEM picture of amorphous calcium phosphate
Figure 2. Degradation enhancement of the biopolymer PLGA
by incorporation of a-TCP nanoparticles (100/0: pure PLGA, 70/30: 30% a-TCP in
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