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Topics Covered
Introduction
Analytical Innovations in Pharmaceutical Industry
Classic Analytical Methodologies Throughout History of Drug Discovery
New Challenges with the Age of Nanomaterials
Introduction
Hecus
X-Ray Systems, founded in 1992, is traditionally specialized on innovative
system solutions for X-Ray nanostructure analytics. The strong focus on
small-angle X-ray methods - the Otto-Kratky heritage - serves a wide community
of researchers and engineers, who need SAXS and related techniques as practical
and reliable tools in their challenging laboratory practice, and who want to use
the techniques routinely.
Analytical Innovations in Pharmaceutical Industry
In pharmaceutical industry, analytical innovations are just as important as
the development of new products. Just consider the crucial roles played by chromatographic
(e.g. HPLC, FPLC), spectroscopic (e.g. MR, MS) and thermodynamic methods.
Classic Analytical Methodologies Throughout History of Drug Discovery
Throughout the history of drug discovery, two analytical methodologies have
been classics: thermal/calorimetric analysis, and X-ray diffraction. Already
a century ago they have led to the discovery of a new class of materials, the
liquid crystals. X-ray diffraction has always been indispensible in finding
the structure of any new compound discovered, and DSC has become daily routine.
New Challenges with the Age of Nanomaterials
With the age of nanomaterials, structural and thermal analytics are faced with
new challenges: it is not just the molecular structure that determines product
quality, but their nanostructure: this determines important properties such
as compactability, stability, bioavailability ect. Therefore, the normal techniques,
e.g. of X-ray powder diffraction are no longer sufficient and have to be supplemented
by a technique that has long been known, but largely ignored: X-ray small-angle
scattering (SAXS), which allows the precise analysis of nanosize and shape.
With the advent of high-brilliance micro-X-ray sources, this has recently also
found broader use in ‘normal’ research laboratories, not just on
large synchrotrons. Moreover, the combination of this structure analytical technique
with micro-calorimetry in one instrument has become feasible. The documentation
of nanostructural and thermal properties of complex formulations, e.g. different
amorphous states is becoming broadly accessible. This will certainly have enormous
impact not just in discovery and development, but also on the creation of new
IP and product value.
Source: Hecus X-Ray Systems
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