One-Step Process for Production of Drug Nanoformulations with Precise Particle Sizes

By AZoNano

Table of Contents

Introduction
Advantages of Nanoformulation
Nanoformulation Technology
The Nanoformulation Process
About Nanocopoeia

Introduction

A number of challenges are faced by pharmaceutical companies in maintaining and developing drug therapies, which include:

  • Improvement of drug effectiveness lost to insolubility; and
  • Extension of the life on an existing drug as the patent nears expiration. For example, it is estimated that 40-50 percent of potentially useful compounds emerging from the drug discovery process are not soluble in water, and thus "wasted." Also, companies face pressure to develop new formulations to extend the market life of existing branded drugs as generic forms enter the market.

Nanoformulation successfully addresses both these challenges that involves formulating compounds into nanoscale materials.

Advantages of Nanoformulation

The creation of drug nanoparticles, also known as nanoformulation, drastically increases surface area, hence making substances more soluble, bioavailable, effective and efficient. This enables the rescue of compounds that are otherwise discarded.

Futhermore, nanoformulation can also improve drug performance by speeding onset of action—enabling alternative delivery routes such as across the skin or mucous membranes, or even targeting specific tissues.

Nanoformulation Technology

Nanocopoeia's proprietary ElectroNanospray (ENS) formulation technology produces accurate and ultra-pure nanoparticles in an innovative one-step process. The processes of competitors are inherently limited in their ability to produce constantly pure particles within a specified size range and distribution or to produce coated particles.

With ENS, precision particle sizes can be designed to suit the specific application needs from 20-200 nm. Additionally, the device is capable of applying a coating to the particles in a single-process step that produces a drug-loaded core operating at ambient temperature and pressure.

The Nanoformulation Process

Figure 1 shows a schematic view of a single spray functional unit of the nanoparticle generator. The capillary tips can be massed in accurate configurations to obtain high throughput operation.


Figure 1. Schematic of the ElectroNanospray spray unit

About Nanocopoeia

Built on a foundation of revolutionary intellectual property, Nanocopoeia has grown into a major nanotechnology player in just 10 years. With beginnings at the University of Minnesota dating back to 2001, the company formally began operations in late 2003 after obtaining worldwide exclusive rights to the patent portfolio developed by Drs. David Pui and Da-Ren Chen. The core patents obtained from the University of Minnesota cover the use of ElectroNanospray™ to create nanoparticles out of virtually any material that can be put into solution or suspension. That patent estate has undergone continual updating and enhancing to broaden Nanocopoeia's claims both through the University and by the company during its operation.

This information has been sourced, reviewed and adapted from materials provided by Nanocopoeia.

For more information on this source, please visit Nanocopoeia.

Date Added: Jul 7, 2012 | Updated: Jun 11, 2013
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