Calcium Phosphate (Ca3(PO4)2) Nanoparticles - Properties, Applications

Topics Covered

Chemical Properties
Physical Properties
Thermal Properties
Manufacturing Process


Engineered nanoparticles are designed and produced with very specific surface properties, chemistry, size and shape. The behavior of nanoparticles depends more on surface area than particle composition itself. However, relative surface area is one of the principal factors that enhance their electrical properties, strength and reactivity.

This article discusses the properties and applications of calcium phosphate nanoparticles. Calcium is a Block S, Period 4 element, phosphorus is a Block P, Period 3 element and oxygen is a Block P, Period 2 element.

Calcium phosphate nanoparticles have excellent biocompatibility due to its chemical similarity to human hard tissue. They also provide enhanced immune system stimulation over aluminum salts.

Chemical Properties

The chemical properties of calcium phosphate nanoparticles are outlined in the following table.

Chemical Data
Chemical symbol Ca3(PO4)2
CAS No. 7758-87-4
Group Calcium – 2
Phosphorus – 15
Oxygen - 16
Electronic configuration Calcium – [Ar] 4s2
Phosphorus – [Ne] 3s2 3p3
Oxygen - [He] 2s2 2p4
Chemical Composition
Element Content (%)
Calcium 43.2
Phosphorus 22.3
Oxygen 34.5

Physical Properties

The physical properties of calcium phosphate nanoparticles are given in the following table.

Properties Metric Imperial
Density 2.93 g/cm3 0.105 lb/in3
Molar mass 100.09 g/mol -

Thermal Properties

The thermal properties of calcium phosphate nanoparticles are provided in the table below.

Properties Metric Imperial
Melting point 825°C 1517°F

Manufacturing Process

Calcium phosphate nanoparticles can be produced by reverse microemulsion and hydrothermal processing methods. They can also be prepared using flame spray synthesis.


The key applications of calcium phosphate nanoparticles are listed below:

  • Alternative vaccine adjuvant and delivery system
  • Imaging, biomedical and bioscience applications
  • Coatings, plastics, nanowires and catalyst applications
  • Bone regeneration.

Source: AZoNano


Date Added: Apr 11, 2013 | Updated: Sep 10, 2013
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