Bulk Pharmaceuticals Production Using Nanofiber Technology

By AZoNano.com Staff Writers

Topics Covered

Introduction to Electrospinning
Nanofiber Production Using Electrospinning
Benefits of Electrospinning Technology
Polymer Selection
Industrial Nanospider Technology
About ELMARCO

Introduction to Electrospinning

Electrospinning is the key process used in the formation of nanofibers. The dissolution of the drugs in a polymer solution has to be performed using different solvents such as acids, alcohols, water, up to cyclohexanone, ethylacetate, dimethylsulfoxide, dimethylformamid, and much more.

Nanofiber Production Using Electrospinning

The solution is fed into the electrospinning equipment and a high voltage is applied between electrodes. This results in the formation of nanofibers, which go up towards the opposite electrode and get deposited onto the carrier substrate. This carrier substrate may or may not be incorporated in the final dosage form. It is essential that nanofibers are generally created under atmospheric pressure and room temperature in the process of electrospinning.

Benefits of Electrospinning Technology

  • A wide selection of polymers
  • Uniformity of nanofiber layer
  • Possibility to lead pharmacokinetics
  • Spinnability in a variety of pH values depending on solvents
  • Residual solvents in the range of ppm

Polymer Selection

Polymers suitable for electrospinning and pharmaceutical purposes belong to the category of GRAS polymers, which have FDA approval or are monographed in the United States and by European Pharmacopoeia. These polymers include polycaprolactone, polylactide acid, chitosan, hydroxypropyl cellulose, polyvinylalcohol, polyvinylpyrrolidone, and much more.

Industrial Nanospider Technology

The future of nanotechnology-based drug delivery systems relies on the ability to scale-up the manufacture, which is a challenging task for a majority of the known technologies. The Nanospider technology from Elmarco is engineered for industrial scale production of nanofibers and has hold potential to be applied for bulk pharmaceutical production across many pharmaceutical fields.

About ELMARCO

Elmarco is the industry's first supplier of industrial scale nanofiber production equipment. Partnerships with global industrial leaders and universities form the foundation for success of the company. Elmarco's unique Nanospider™ technology is designed for ease of use, scalability, modularity and flexibility in producing the highest quality nanofibers.

Nanospider™ technology is a patented, needle-free high voltage, free liquid surface electrospinning process. The technology is based upon the discovery, that it is possible to create Taylor Cones and the subsequent flow of material not only from the tip of a capillary, but also from a thin film of a polymer solution.

The technology enabled Elmarco to build industrial scale production equipment with out nozzles, needles or spinnerets.

Nanospider™ technology allows the production of nanofibers from polymers solved in water, acids or bipolar solvents as well as from melted polymers and is suitable for the production of organic and inorganic fibers. This versatile technology is easily adapted to a variety of process parameters for the optimization of the specific properties of the produced nanofibers.

This information has been sourced, reviewed and adapted from materials provided by ELMARCO.

For more information on this source, please visit ELMARCO.

Date Added: Dec 6, 2013 | Updated: Dec 6, 2013
Ask A Question

Do you have a question you'd like to ask regarding this article?

Leave your feedback
Submit