Engineered Nanopores for Bioanalytical Applications
The use of nanopores enables single molecule measurements and the observation of how individual members of a molecular population behave and interact in real-time. The ability to perform such sensitive and selective measurements is extremely valuable in applications such as DNA analysis, immunoassays, environmental monitoring, and forensics where small sample volumes and low analyte concentrations are the norm to work with. The use of nanopores (i.e. natural or man-made molecular membrane holes) provides the opportunity for analysis at the single-molecule level.
The movement of substances through nanometre-sized pores in solid-state or biological membranes has attracted enormous attention over the last decade in both academia and industry.
Engineered Nanopores for Bioanalytical Applications is the first to explore both the development and application of nanopores with practical analytical applications as the primary focus. These nanoscale analytical techniques have exciting potential as they can be used in applications such as DNA sequencing, DNA fragment sizing, DNA/protein binding, and protein/protein binding.
Importantly this book aims to provide a solid professional reference on nanopores for readers in both academia and industry, and engineering and biomedical fields. In addition, the aim of this book is to share with the scientific and engineering communities the experimental and fabrication methods necessary to carry out nanopore-based experiments for developing new devices.
Engineered Nanopores for Bioanalytical Applications is aimed at Biomedical Engineering; Applied research scientists / engineers involved in the applied R&D areas of bio micro-nanofluidics, genetic engineering, Micro/nanofabrication, BioNEMS, bionanomaterials; Pharmaceuticals Engineers and Biotechnology Industry Scientists working on drug discovery, drug delivery methods, safety and drug screening; Biomedical laboratory researchers working on new methods for Tissue Engineering, Stem Cells, and Regenerative Medicine technologies; BioNEMS , biosensors, and micro- nanofluidics industries.
Key features of Engineered Nanopores for Bioanalytical Applications include:
- Includes application case studies for detection, identification and analysis of biomolecules and related functional nanomaterials
- Introduces the techniques of manufacturing solid state materials with functional nanopores
- Explains the use of nanopores in DNA sequencing and the wider range of applications from environmental monitoring to forensics
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