The DynaPro® Plate Reader II performs high-throughput, automated dynamic light scattering (DLS) measurements on macromolecular and nanoparticle samples directly in situ in industry-standard 96, 384, or 1536 well microplates, using as little as 1.5 µL of sample and 5 seconds acquisition time per well.
Without any sample carry over concerns, these features significantly improve formulation screening for aggregation, particle size, thermal stability (via the unfolding temperature TM or aggregation temperature Tonset), colloidal stability (via the diffusion interaction parameter kD or D1), and even the viscosity of highly concentrated protein solutions.
The DYNAMICS® software for data acquisition, control and analysis offers an API which supports full integration with industry leading liquid handling robotics. Samples can be loaded in duplicate or triplicate, and scanned several times, providing a true measure of data reproducibility and repeatability. Outside of the formulation lab, DLS measurements can be performed in the DynaPro Plate Reader in less time and without the difficulties of traditional cuvette-based DLS.
- Range of hydrodynamic radius Rh: 0.5 nm to 1000 nm
- Sensitivity: 0.125 mg/mL lysozyme
- Temperature range: 4°C to 85°C
- DYNAMICS software provides a comprehensive set of analyses for macromolecules and nanoparticles
The DynaPro Plate Reader II also has an integrated camera, which snaps a photo of each microwell for diagnostic purposes, to determine the presence of a precipitate, bubble, or an empty well.