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BioScope Catalyst Atomic Force Microscope (AFM) from Bruker

The BioScope™ Catalyst™ Atomic Force Microscope (AFM) with ScanAsyst™ provides uncompromised high-resolution optical imaging capability and thermally limited force measurements and features numerous hardware and software features that make it easier than ever to realize the unique benefits of combining atomic force microscopy and light microscopy.

Bruker's exclusive Microscope Image Registration and Overlay (MIRO™) feature automatically imports and rescales light microscope images, allowing them to be used to direct the location of AFM imaging and force measurements, and the Perfusing Stage Incubator accessory maintains ideal cell culture conditions for long-duration live cell studies. With its open-access design, unique integration software, and bio-friendly features and accessories, the BioScope Catalyst is the highest performance, most completely integrated, easiest to use life science AFM available on the market today.

The BioScope Catalyst and AFM-Raman

The Integrated AFM-Raman Imaging System (IRIS) Module for Bruker Atomic Force Microscopes enables the seamless blend of AFM and Raman spectroscopy by combining chemical or crystallographic information (Raman spectroscopy) at high spatial and spectral resolution, with the most advanced nanoscale mechanical, electrical, and thermal atomic force microscopy characterization. The IRIS Module supports both the Innova SPM and BioScope Catalyst AFM systems, providing combined-technique experiment control for advanced research in both materials and life sciences applications. To create an AFM-Raman spectroscopy system, simply select your AFM platform and add a HORIBA Scientific, Renishaw, or Princeton Instruments Raman microscope. For life sciences applications, you can also add an inverted light microscope from Zeiss, Leica, Olympus or Nikon. However you tailor your system, your application will benefit from the best tip preservation and lowest drift, guaranteeing that alignment is preserved even over the optical integration times necessary to interrogate weak Raman scatterers.

AFM Imaging Live Biological Samples

The promising PeakForce QNM imaging mode and Peak Force Tapping technique applied by the BioScope Catalyst look to provide the acquisition speed and quality resolution needed to measure the mechanical properties of living cells ex vivo — thereby surpassing the previous limitations of force spectroscopy. Our exciting life sciences application note gives an overview of the biological samples that can be imaged and the unique information that can be extracted from the atomic force microscopy data.

Fluorescence image of labeled HeLa cells from which MIRO was used to guide AFM. Data courtesy of Alexandre Berquand, Andreas Holloschi, and Petra Kioshis, FachHochschule Mannheim, Germany

The New Standard for Atomic Force Microscopy and Light Microscopy Integration

  • MIRO software allows optical images to precisely guide AFM imaging and force measurements
  • Create correlated AFM and optical datasets with flexible offline analysis features
  • MIRO makes the atomic force microscope a natural extension of the optical microscope

Uncompromised Performance from Atomic Force Microscopy and Light Microscopy

  • High-resolution imaging capability
  • Thermally limited (PicoForce-quality) force measurements
  • Supports most microscopes, condensers, and objectives for uncompromised optical performance

Easiest to Use and Most Productive Life Science AFM Microscope

  • Exchanging probes and laser alignment is made easy with a convenient probe load stand and EasyAlign™ accessory
  • New "Experiment Selector" automatically configures the software for the most common modes and applications

Simple, Effective Solutions for Biological Samples

  • Easy mounting for all common sample substrates, including slides, cover slips, and petri dishes
  • Micro-volume perfusion accessory provides ideal solution for applications that utilize expensive reagents
  • Petri dish perfusion accessory with heating capability allows long-duration cell studies
  • Perfusing Stage Incubator accessory enables long-duration cell studies, maintaining cell viability from hours to days
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