The Zetasizer Nano ZS brings you the practicality of a maintenance-free system with the versatility of multi-parameter measurements in a single compact unit.
Non-invasive back scatter (NIBS) technology takes particle sizing to new levels of sensitivity in the 0.6nm to 6 micron range. The new Zetasizer Nano ZS is the choice for the accurate, reliable and repeatable size analysis of particles and molecules in solution.
The new Zetasizer Nano ZS offers the highest ever sensitivity, accuracy and resolution for the measurement of zeta potential. This is achieved by a combination of laser Doppler velocimetry and phase analysis light scattering (PALS) in Malvern's patented M3-PALS technique. Even samples of very low mobility can be analyzed and their mobility distributions calculated.
Connect the Zetasizer Nano to your chromatography system for use as an absolute light scattering detector. Just position after the last detector in your SEC/ GPC system. The size and intensity are plotted in real time as the material is eluted from the column. Averages, peak positions and molecular weights of each peak are calculated automatically at the end of the measurement.
Using static light scattering (SLS) and the classical Debye plot, the molecular weight of random coiled polymers up to 5 x 105 Da as well as globular polymers and proteins up to 2 x 107 Da can be determined without the necessity for multi-angle measurements.
By enabling temperature controlled measurements, the Zetasizer Nano ZS is particularly suited to our work here at USF. With it we have been able to monitor the effect on the hydration of proteins by salt ions in solution, measuring the hydrodynamic radius of proteins down to plus/minus one tenth the diameter of a water molecule. Interestingly we found that neither chaotropic or cosmotropic salt ions affected overall protein hydration up to salt concentrations of 1M.
Dr Martin Muschol, Assitant Professor, Department of Physics, University of South Florida