The Viscotek Triple Detector Array is sold as part of the Viscotek TDAmax system, or as a stand-alone module and incorporates RI, light scattering and viscosity detectors. The columns and integrated detectors are completely temperature controlled up to 80°C to ensure optimum detector stability, and the detectors being series ensures maximum sensitivity. Each detector offers complimentary data on the macromolecules being studied.
In its tetra detector format, adding an ultraviolet photodiode array (UV-PDA) detector offers additional compositional data of copolymers and conjugated proteins.
The detectors can determine concentration, intrinsic viscosity, molecular weight and molecular size Rh and Rg of natural and synthetic polymers and proteins. Applications include studying molecular weight, aggregation, conjugates and copolymers, and molecular structure.
The key features of the Viscotek TDA 305 are:
- Right angle light scattering (RALS) has highest signal to noise for absolute molecular weight of small polymers and proteins.
- Absolute molecular weight of synthetic and natural polymers without extrapolation using Low angle light scattering (LALS).
- Protein and polymer structure (including branching) information using intrinsic viscosity detector.
- High-sensitivity RI detector specifically designed with multi-detection GPC/SEC in mind.
- Molecular size in terms of hydrodynamic radius (Rh) and Rg.
- Copolymer or protein conjugate composition using multi-wavelength UV-PDA detector
- 21 CFR part 11 compliant.
- Full suite of calibration and GPC/SEC calculation types.
Using Viscotek to characterize new polymer candidates we have been able to pre-select only the most interesting for further study. This has allowed us to reduce the number of more expensive and time consuming NMR investigations.
Stephane Cornelis, Global Business Service - Analytical Sciences, Dow Corning Europe S.A.