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Time Series of CM15 Antimicrobial Activity on Live E. coli Cells

This video shows the time series of CM15 antimicrobial activity on live E. coli cells. The images were recorded every 18s at a resolution of 1024 x 256 pixels. Every seventh image in the time series is shown once the effects of CM15 were first observed at ~7.5min.

Dimension FastScan Bio AFM (atomic force microscopy) from Bruker Nano Surfaces showed an increase in the roughness of the bacterial cell surfaces that is believed to be the direct result of the incorporation of CM15 into the outer membrane. The onset of these changes was observed to occur at different times for individual cells.

Run Time – 0:12sec

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