DPN-Created Nanopattern Chips Provide Unparalleled Control of Stem Cell Differentiation

Published on May 5, 2009 at 10:39 AM

NanoStem Cell, a division of NanoInk, Inc., announced today that Professor John Hunt of the UK Centre for Tissue Engineering (UKCTE) at the University of Liverpool will present the results of an ongoing, collaborative research project leveraging NanoInk's proprietary Dip Pen Nanolithography® (DPN®) technology to create homogenous nanopattern biochips and control cell functionality in a predictable and reproducible manner. Professor Duncan Graham of the Centre of Molecular NanoMetrology at the University of Strathclyde in Glasgow, Scotland is also collaborating on the project. Professor Hunt will present this exciting data at the NanoScience Technology Institute Nanotech Conference + Expo 2009 being held in Houston, Texas, Sunday, May 3, to Thursday, May 7.

The data will highlight that the DPN-created nanopattern chips provide unparalleled control of stem cell differentiation including keeping adult stem cells in an undifferentiated form as well as inducing differentiation to a homogenous population of a targeted primary cell type, depending on the chemistry and topography of the pattern.

"Through our collaborative efforts and use of our DPN nanopatterning technology, we will be able to provide pharmaceutical and biotech companies with access to large and renewable sources of homogeneous populations of differentiated stem cells for drug discovery, drug development and high throughput screening," said Haris Jamil, Vice President of NanoInk's NanoStem Cell Division.

"We are very excited about the results we are generating in this project," said Professor John Hunt, UKCTE. "The data shows that NanoInk's proprietary Dip Pen Nanolithography technology can be used to present environments suitable for the guidance and control of stem cells for development into functional phenotypically defined populations of cells."

"The project and subsequent data generated up to now are impressive. There is great potential in this project and it is definitely worth talking about," said Professor Duncan Graham, Centre of Molecular NanoMetrology at the University of Strathclyde. "Each component of this collaboration is essential in moving the project forward and generating tangible results in drug discovery, drug development and regenerative medicine."

"The results we are generating in this exciting effort will generate substantial cost savings," said James M. Hussey, chief executive officer of NanoInk. "But more importantly, the research moves us a step closer toward providing options for patients that may require a regenerative approach to treatment."

The project results follow an announcement in March 2009 detailing the joint research and licensing agreements between NanoInk, the UKCTE at the University of Liverpool in Liverpool, England, and the Centre of Molecular NanoMetrology at the University of Strathclyde in Glasgow, Scotland.

Professor Hunt's presentation will be on Wednesday, May 6, at 10:30 a.m. Central, at the George R. Brown Convention Center in room 370BE.

For more information about the NSTI Nanotech Conference & Expo 2009, please visit www.nsti.org/Nanotech2009/.

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