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Bruker Daltonics Launches Next-Generation Ultra-Sensitive Ion Trap

Published on May 11, 2009 at 7:16 AM

Bruker Daltonics today launches the next-generation ultra-sensitive, ion trap amaZon™ series. Delivering 10x improved MS/MS sensitivity over current platforms, novel technology for accelerated data acquisition, significantly enhanced mass resolution, and second-generation fast and sensitive ETD/PTR capabilities, this unique, highest performance ion trap delivers unrivalled data quality and extreme flexibility for a broad variety of applications.

Bruker's new amaZon is the First Ion Trap with Dual Ion Funnel Technology for a 10x Sensitivity Boost, Second-Generation ETD for Proteomics, Mass Resolution up to 20,000, and Highest Acquisition Speed (Photo: Business Wire)

The amaZon builds upon Bruker’s long experience in ion trap technologies, and is designed to enhance capabilities in research areas such as bottom-up proteomics, high-throughput and ultra-sensitive PTM analysis, metabolomics, compound screening and identification, and detailed chemical and structural analysis. The amaZon series is offered in two versions: amaZon ETD for proteomics, and amaZon X for small molecule analysis and applied markets.

The new amaZon incorporates key inventions for unprecedented ion trap capabilities:

  • First commercial introduction of a double ion funnel transfer in ion traps, delivering a new benchmark for sensitivity
  • Unrivalled scan speed of 52,000 u/sec at better than unit resolution for fastest UPLC applications and maximum duty cycle in data-dependent MS/MS and MSn
  • Ultimate ion trap mass resolving power up to 20,000 in full scan mode across the 50-3000 m/z range: in combination with Bruker’s patented peak recognition technology SNAP IITM, the amaZon provides isotopic peak resolution even for highly charged ion species in ETD/PTR fragment spectra for the confident determination of their monoisotopic masses.
  • The latest ETD/PTR technology offering the most efficient, extremely robust and sensitive peptide and protein fragmentation, as well as high-throughput PTM analysis. Building upon the very successful ETD technology commercialized first by Bruker, the combination of bottom-up CID or ETD and top-down ETD/PTR provides new methodologies for detailed protein characterization.
  • Zero Delay Alternating™ acquisition for high-speed ion polarity switching without sensitivity and time compromise. Up to 20 Hz MS data acquisition in both polarities is ideal in combination with fast UHPLC separations. Supported by spectral MSn libraries, the amaZon is the ultimate ion trap mass spectrometer for MS/MS based multi-compound screening.

Bruker Daltonics Vice President Dr. Arnd Ingendoh commented: “The performance of the amaZon will completely redefine the use of ion traps across an increasing range of application areas. With new, unparalleled levels of sensitivity, acquisition speed and mass resolution combined with ease-of-use, smart automation and an array of software modules for faster high-value information generation, the amaZon offers a new level of performance and confidence in many small molecule and applied market segments. In proteomics, the amaZon is a very powerful ESI-MS/MS system with ultra-sensitive, fully automated ETD/PTR, and represents a perfect complement to MALDI-TOF/TOF technology for the broadest array of proteomic analysis capabilities.”

The revolutionary new amaZon will be highlighted at Bruker's Annual Users Meeting on Sunday, May 31st, 2009 before the 57th ASMS Conference on Mass Spectrometry in Philadelphia, PA. For more information on this event, please visit www.bdal.com/asms2009. For further product information please visit www.bdal.com/amaZon.

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