Carl Zeiss has developed
a unique series of solutions addressing the different methods for brain mapping
and soft tissue imaging. "Scientists are right now attacking one of the last
secrets of mankind: imaging and reconstruction of the brain", Dr. Dirk Stenkamp,
Member of the Board at Carl Zeiss SMT explains. "We specifically enable the
acquisition and analysis of cell images at ultra-high resolution. For that purpose
we have developed an extensive range of solutions, based on the sophisticated
use of advanced electron and ion-beam microscopes", Stenkamp adds.
At center stage, with a combination of a special detector system and large
framestore, the SIGMA™ FE-SEM is enabling extremely fast imaging of huge
areas of thin sections. "With this system, which is currently being evaluated
by several leading research institutes worldwide, throughput is increased by
a factor of 100", application product specialist Dr. Stewart Bean from
Carl Zeiss SMT´s Cambridge facilities says.
Extremely thin sections can be investigated by simultaneous milling and imaging
using ZEISS CrossBeam® workstations like the NVision 40 or the new AURIGA.
This leading-edge FIB/SEM instrument provides high resolution and now also features
the possibility of investigating nonconductive samples using a unique local
charge compensation method. NVision CrossBeam systems are already successfully
in the field for soft tissue analysis at various institutes, including EPFL
in Lausanne (Switzerland) and many others.
The ORION® Helium-ion microscope offers totally new imaging possibilities.
"Biological samples especially profit from the unprecedented depth of
focus and the high contrast, that are inherent characteristics of imaging with
helium ions," Mohan Ananth, Product Manager and application specialist
at the US headquarters of Carl Zeiss SMT points out.
Whenever resolution below one nanometer is required, the LIBRA® 120 PLUS
energy filtering TEM from Carl Zeiss SMT provides the highest contrast imaging
of soft tissue. LIBRA 120 PLUS especially matches the extreme demands in revealing
structural and 3-D information of beam sensitive or frozen hydrated specimens
at the nano scale. With the LIBRA 200 FEG energy filtering TEM, resolution in
the Angström and even sub-Angström range can be provided.
"We are in dialogue with researchers all over the world in order to meet
their demanding requirements – now and in the future and as a part of
our company mission. We are proud to be making a contribution to research work
that will change our world", Stenkamp explains.