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Centre for Molecular Nanometrology Uses Nanosight to Develop New Biosensors

Published on September 11, 2009 at 7:14 PM

The Centre for Molecular Nanometrology at the University of Strathclyde has selected an LM10 characterisation system from Nanosight to aid in their research and development of new biosensors.

Dr Alastair Wark, Lecturer at the University of Strathclyde’s Centre for Molecular Nanometrology and principal user of NanoSight technology for nanoparticle characterisation

Lecturer, Dr Alastair Wark's research interests are based around the preparation, functionalisation and application of plasmonic nanomaterials. The use of such nanometre-scale materials and tools is opening up exciting new avenues for the investigation of biomolecular interactions and biological systems with unprecedented sensitivity and spatial accuracy.

Other characterisation techniques such as UV-VIS adsorption spectroscopy and DLS (dynamic light scattering) are useful for bulk averaging measurements but it is the ability to visualise individual nanoparticles one at a time that drew former postdoctoral researcher Dr Robert Stokes, whilst working with Professor Duncan Graham, to select the NanoSight NTA system. This has catalysed the current research being led by Dr Wark who reports “the NanoSight provides an intuitive way of sensing particles and being able to work dynamically in biocompatible liquids collecting multiple single sets of particle information gives statistical credibility to the data.”

This initial work is leading to developments for biosensors involving the controlled aggregation of functionalised nanomaterials in the presence of a specific target biomolecule. The ability to monitor this process in solution using particle-by-particle measurements cannot be achieved with bulk characterisation techniques.

NanoSight's NTA approach has been shown to ideally suit such research activities and, with the ability to not only look at spherical particles but also characterise rod-like materials, makes the system an extremely powerful nanoscale research and development tool.

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