Posted in | Nanomaterials | Nanoanalysis

Methods Available for Submicron and Nano-Sized Particle Characterisation

Published on February 1, 2010 at 8:09 PM

“Optical methods for particle size and zeta potential determinations with an overview of acoustical techniques” will be the subject of a presentation in March 2010 by Fraser McNeil-Watson, manager of the Novel Measurement Group at Malvern Instruments at a meeting on the ‘Characterisation of sub-micron and nano-sized particles’.

The one-day technical meeting, organised by the Particle Characterisation Interest Group of the Royal Society of Chemistry and The Joint Pharmaceutical Analysis Group, takes place on 17 March 2010 at the Royal Pharmaceutical Society in London (UK). The programme includes presentations on different methods available for submicron and nano-sized particle characterisation and will discuss method validation and checking, as well as exploring important aspects of sample preparation and dispersion.

Malvern’s Zetasizer Nano series of particle characterization systems measures particle size, zeta potential and molecular weight. The novel measurement technology and patented optics built into the systems make them equally applicable to characterizing high concentration colloids and nanoparticles of all types, through to measurement of dilute proteins and macromolecules in their native state, requiring as little as 12 microlitres of sample.

Zetasizer Nano systems use the combination of patented NIBS (non-invasive back-scatter) optics and dynamic light scattering (DLS) to measure the size of particles and molecules from 0.6 nm to 6 microns. Zeta potential measurement in both aqueous and non-aqueous dispersions uses the latest M3-PALS technology, while molecular weight is an absolute measurement using static light scattering. A choice of measurement cells includes a unique disposable zeta potential cell that ensures no cross contamination of samples, and a high concentration cell for zeta potential measurement. All systems are compatible with the MPT-2 autotitrator, enabling the automation of pH, conductivity and additive trend measurements.

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