Inc., a global leader in nanotechnology, is pleased to announce that its
NanoFabrication Systems Division instruments have now been proven to support
three new applications of importance to biological research.
Leveraging patented Dip Pen Nanolithography® (DPN®) technology, NanoInk
has demonstrated the successful use of its NLP 2000 System for functionalizing
biosensors, patterning functional hydrogels, and printing multiplexed protein
Launched in 2009 as a tool for bioscience research, the NLP 2000 System is
a simple, user-friendly desktop nanolithography platform. It can deposit sub-micron
sized features of a wide variety of materials on virtually any planar surface.
The NLP 2000 System employs high resolution nanopositioning stages, greatly
simplifying the deposition process. With the launch of three new Application
Notes that further validates the utility of the NLP 2000 System in biological
applications, NanoInk promises to be a valuable partner to the life science
Tom Warwick, NanoInk's general manager of sales and marketing, explained that
the first of these Application Notes demonstrates successful use of the NLP
2000 System for the functionalization of cantilever-based biosensors. Micro-
and nanocantilevers are the most simplified microelectromechanical (MEMS) based
devices available for analyte sensing applications. Nanocantilever biosensors
are easily multiplexed and can achieve attogram level sensitivity, so they are
particularly well-suited to disease screening, point mutation analysis, blood
glucose monitoring, and chemical and biological warfare agent detection. NanoInk
has developed a simple and reliable methodology for functionalizing micro- and
nanocantilevers using an NLP 2000 System protein deposition approach.
A second new bioscience NLP 2000 System Application Note supports the printing
of functional hydrogels. Hydrogels are three-dimensional cross-linked polymer
networks that demonstrate physical characteristics very similar to those of
natural tissue. As a result, functional hydrogels fabricated at sub-cellular
scales have utility in proteomic analyses, drug screening, biological sensor
development, and cell culture applications. NanoInk has validated the feasibility
of generating consistent and reproducible nanoscale functional PEG hydrogel
patterns with the NLP 2000 System.
"With our third new Application Note, we clearly demonstrate that the
NLP 2000 System, which is capable of printing multiple substances with nanometer
precision at defined locations, is ideal for creating multiplexed protein nanoarrays.
Compared to conventional protein microarrays, nanoscale arrays have the benefit
of reduced sample and reagent quantities (which lowers assay cost), higher detection
sensitivity, improved ability to interrogate sub-cellular features, and better
compatibility with lab-on-a-chip technologies," added Warwick.
NanoInk is dedicated to developing and supporting a wide range of biological
applications for the NLP 2000 System. These three new Application Notes are
just the first step toward proving this commitment.