Drs Kevin Mattison*, Ulf Nobbmann and Jason Sanchez of Malvern Instruments will
lead a workshop on 'Characterization techniques for protein therapeutics' - at
the 7th Annual PEGS - Protein & Antibody Engineering Summit being held in
Boston MA, from 9-13 May 2011.
As a corporate sponsor, Malvern Instruments will also be exhibiting and
company experts will be on hand to discuss light scattering, size exclusion
chromatography (SEC) and dynamic imaging technologies.
Zetasizer µV with OmniFACE and OmniSEC, a new SEC-LS (size exclusion chromatography - light scattering) detector package dedicated to protein analysis.
The workshop will cover the theory and general application of both
traditional and emerging technologies suitable for protein therapeutic
characterization, across the applicable size range of 1 nm to 100 µm.
Participants will seek to answer questions such as:
- What's the difference between Tm measured by DSC, CD, & DLS?
- Can DLS be used to confirm SEC results?
- What's the relevance of protein charge on formulation stability?
- Can particle counting be achieved in the 100 nm to 1 µm size range?
- What role does protein aggregate "morphology" play?
Malvern solutions for characterizing proteins and other macromolecules
include: the Zetasizer µV with OmniFACE and OmniSEC, a new SEC-LS detector
package dedicated to protein analysis; Zetasizer Nano systems, which use dynamic
and static light scattering to measure size and molecular weight; Viscotek size
exclusion chromatography systems/detectors for molecular weight and molecular
structure characterization; Sysmex FPIA-3000 for dynamic imaging, size and shape
characterization of protein aggregates.
*Kevin Mattison is Principal Scientist, Bioanalytics; Ulf Nobbmann is Senior Applications Specialist, Nanometrics; and Jason Sanchez is Product Manager GPC/SEC Technologies, all at Malvern Instruments.