At the 2008 World Molecular Imaging Congress, Bruker
BioSpin introduces HyperQuant(TM), a bench-top NMR reader for precisely
quantifying both the magnetic hyperpolarization as well as the thermal polarization
of a sample. The HyperQuant applies time-domain nuclear magnetic resonance (TD-NMR)
spectroscopy, a technology similar to magnetic resonance imaging (MRI).
Magnetic hyperpolarization promises to be a useful technique with potential
to boost contrast in MRI and sensitivity in solid-state NMR. Hyperpolarization
provides a means to increase the nuclear magnetic polarization by orders of
magnitude compared to the thermal Boltzmann polarization. Today, hyperpolarization
can be achieved by various mechanisms, including DNP (dynamic nuclear polarization)
and parahydrogen-induced polarization (PHIP). Typically, carbon-13 labeled samples
are utilized because of their preferential NMR properties.
The key applications requirement for Bruker BioSpin’s new HyperQuant
is that the polarization enhancement factor needs to be determined very precisely.
Therefore, it is crucial to quantify both the hyperpolarization and the thermal
polarization on the very same sample. The proprietary HyperQuant utilizes a
unique permanent magnet combined with an innovative probe design (patents applied
for) and novel NMR pulse sequences to enable the quantification of the thermal
polarization of 13C-labeled samples using volumes as low as 1 ml. In this manner,
hyperpolarization enhancement factors can be obtained directly and with confidence
on the sample of interest, without having to go via a separate calibration reference.
The new HyperQuant offers a complete easy-to-use turnkey solution for any researcher
developing new MRI or NMR applications for hyperpolarization.