(Nasdaq:FEIC), a leading provider of three-dimensional (3D) molecular, cellular
and atomic-scale imaging systems, today announced that the University of California
at Los Angeles (UCLA) has installed a multi-million dollar Titan Krios(tm) transmission
electron microscope (TEM) from FEI. In an effort to understand the causes of
disease, UCLA's Dr. Hong Zhou, director of the newly-established Electron Imaging
Center for NanoMachines (EICN), part of the California NanoSystems Institute,
has initiated high-resolution molecular imaging studies using the new Titan
The Titan Krios is specifically designed for 3D molecular imaging applications
where samples are imaged at cryogenic temperatures, which preserves the biological
samples in their native hydrated state. The microscope's ability to generate
images used in the creation of 3D molecular structures with resolutions as small
as a few tenths of a nanometer allows scientists to investigate the structure
and function of biological nanomachines at the molecular scale.
"We are very pleased to begin the next phase of our partnership with UCLA,"
said Matthew Harris, FEI's vice president and general manager of the Life Sciences
Division. "Dr. Zhou and his colleagues recently achieved breakthrough results
in 3D molecular reconstruction with resolution better than four Angstroms using
an FEI Tecnai Polara(tm) TEM. We are confident that Dr. Zhou will continue to
push the boundaries of molecular imaging, and we look forward to supporting
him with many groundbreaking discoveries using the Titan Krios."
Dr. Zhou adds, "The advanced optics, automation and cryo capabilities
of the Titan Krios are absolutely essential for our research in nanobiology
and nanomedicine. Developments in these areas will expand opportunities to contribute
to major advances in rational drug design and targeted delivery, and ultimately
advance us towards biology-inspired nanomachines."
Recent advances have made cryo-electron microscopy (cryo-EM) an important imaging
tool for major applications in both medicine and nanobiological research. Researchers
can use cryo-EM to visualize a broad range of assemblies or nanometer-scale
structures at near-atomic resolution and in three dimensions. This imaging method
covers a scale range from tens of micrometers to Angstroms and provides valuable
structural information for numerous scientific disciplines including structural
biology, cell biology, medical and pharmaceutical science.
The Titan Krios TEM will be publicly debuted at a symposium entitled, "Advanced
Electron Microscopy in NanoMedicine," to be held October 2-3, 2009, at
the EICN. Featuring in-depth talks by leading structural biologists and poster
presentations by both academic and industrial researchers, the symposium will
cover a wide range of topics, including: cryo-sample preparation; high-resolution
cryo-electron microscopy imaging; and advances in 3D molecular reconstruction
techniques, such as electron tomography and single particle analysis. For registration
and additional information please visit: http://www.cnsi.ucla.edu/electron-microscopy/.