Following the World Health Organization (WHO) declaration of a swine flu
pandemic, NanoPass Technologies
Ltd. (NanoPass) announced today that it has successfully developed a microneedle-based
injection device that could dramatically enhance both the effectiveness and
supply of pandemic flu vaccines.
"As declared by WHO on June 11th, 2009", said Dr Yotam Levin, the
Company's CEO, "the novel A H1N1 influenza has become a phase 6 global
pandemic. There is an imminent need of developing countries, as well as that
of many developed countries, for an adequate supply of pandemic flu vaccines.
Since global capacity is limited and production yield is reported to be low,
novel approaches for vaccine enhancement are of great need." Dr Ofer Sharon,
the Company's Medical Director added, "NanoPass has proven in a randomized
clinical trial, recently published in Vaccine, that it can reduce the dose
of a seasonal flu vaccine by 80% while preserving its efficacy. This effect
is thought to be achieved by targeting the potent specialized immune cells that
reside in the skin. This means that health authorities can use the same amount
of vaccine they have sourced, to vaccinate at least double, if not triple, the
number of subjects, with the same vaccine purchase." NanoPass is designing
clinical studies to demonstrate this significant effect for swine H1N1.
The major global public threat posed by the new H1N1 flu strain demands close
coordination among vaccine manufacturers, governments, technology developers
and global health authorities to manage the supply of vaccines and to ensure
there are enough doses for everyone.
About NanoPass's MicronJet Device
MicronJet is a microneedle-based device for intradermal delivery of vaccines.
The device allows for consistent, reliable, and simple delivery of the vaccine
directly into the skin. It has been shown in multiple clinical trials,[3,4]
that injecting a seasonal influenza vaccine directly into the skin harnesses
this very potent immune organ, and allows for both the reduction of the dose
required for the same immune response ("dose sparing"), as well as
the ability to actually potentiate this response, with the use of equivalent
doses ("increased immunogenicity").
This approach is being tested for a variety of major diseases that do not yet
have an effective vaccine, such as malaria, HIV and tuberculosis.
NanoPass - Transforming device innovation into global health solutions
NanoPass, founded by Dr Shuki Yeshurun, is an Israeli-based private company
developing an innovative delivery device for the enhancement of vaccines and
other large molecules. The Company has proven efficacy and safety in multiple
applications including seasonal flu, insulin delivery and lidocaine for local
anesthesia. MicronJet is approved for marketing in the EU (please see http://www.nanopass.com
for more information), and is about to be registered in additional markets.
The MicronJet is approved for use by health care professionals for intradermal
delivery of drugs and medicinal products that are approved for intradermal delivery.
 Van Damme P, Oosterhuis-Kafeja F, Van der Wielen M, Almagor Y, Sharon
O and Levin Y. Safety and efficacy of a novel microneedle device for dose sparing
intradermal influenza vaccination in healthy adults. Vaccine. 2009 Jan 14;27(3):454-9.
 Belshe RB, Newman, FK et al. Serum Antibody Responses after
Intradermal Vaccination against Influenza. N Engl J Med
 Kenney RT, Frech SA et al. Dose sparing with intradermal injection of
influenza vaccine. N Engl J Med. 2004 Nov 25;351(22):2295-301. Epub
2004 Nov 3.
 Holland D, Booy R et al. Intradermal influenza vaccine administered using
a new microinjection system produces superior immunogenicity in elderly adults:
a randomized controlled trial. JID 2008; 198:650-58.