“Optical methods for particle size and zeta potential determinations
with an overview of acoustical techniques” will be the subject of a presentation
in March 2010 by Fraser McNeil-Watson, manager of the Novel Measurement Group
at Malvern
Instruments at a meeting on the ‘Characterisation of sub-micron and
nano-sized particles’.
The one-day technical meeting, organised by the Particle Characterisation Interest
Group of the Royal Society of Chemistry and The Joint Pharmaceutical Analysis
Group, takes place on 17 March 2010 at the Royal Pharmaceutical Society in London
(UK). The programme includes presentations on different methods available for
submicron and nano-sized particle characterisation and will discuss method validation
and checking, as well as exploring important aspects of sample preparation and
dispersion.
Malvern’s Zetasizer Nano series of particle characterization systems
measures particle size, zeta potential and molecular weight. The novel measurement
technology and patented optics built into the systems make them equally applicable
to characterizing high concentration colloids and nanoparticles of all types,
through to measurement of dilute proteins and macromolecules in their native
state, requiring as little as 12 microlitres of sample.
Zetasizer Nano systems use the combination of patented NIBS (non-invasive back-scatter)
optics and dynamic light scattering (DLS) to measure the size of particles and
molecules from 0.6 nm to 6 microns. Zeta potential measurement in both aqueous
and non-aqueous dispersions uses the latest M3-PALS technology, while molecular
weight is an absolute measurement using static light scattering. A choice of
measurement cells includes a unique disposable zeta potential cell that ensures
no cross contamination of samples, and a high concentration cell for zeta potential
measurement. All systems are compatible with the MPT-2 autotitrator, enabling
the automation of pH, conductivity and additive trend measurements. www.malvern.com/zetasizer