Life Science Applications of the NL50 Nanoparticle Deposition System

The NL50 nanoparticle deposition system is a user-friendly, touch-screen device that produces ultra-pure nanoparticles in a vacuum.

The nanoparticles are directly deposited onto a substrate as required. Vacuum phase nanoparticles do not contain hydrocarbons and can resolve several challenges associated with solution- or powder-based nanoparticles.

Key Characteristics

  • Hydrocarbon-free and ultra-pure nanoparticles
  • Can be directly deposited onto a substrate — provides reliable results on textured or planar substrates without clumping
  • Repeatable control across the surface coverage — offers repeatable results from monodisperse to high porosity
  • Prepare as required — out-of-date nanoparticles need not be discarded again
  • Control nanoparticle sizes from 2 to 20 nm — nanoparticle size can be controlled using deposition conditions
  • Can easily switch between materials — a single tool can be used to deposit an array of materials, such as gold (Au), silver (Ag) and copper (Cu)

Applications

Biosensors

Nano-porous Au electrodes serve as conducting binding sites for bulk molecules in electrochemical biosensors. Present-day projects involve glucose sensors and RNA/DNA sequencing.

Lateral Flow Assays

Au nanoparticles can be functionalized with antibodies, peptides, or proteins to gain cell or molecular specificity both in vitro and in vivo.

SERS — Biological or Chemical Sensors

The optical properties of Ag and Au nanoparticles are utilized to improve Raman spectroscopy signals for chemical, gas and molecular sensors. The gold nanoparticle from Nikalyte showed excellent sensitivity for caffeine ppb levels.

Life Science Applications of the NL50 Nanoparticle Deposition System

Image Credit: Nikalyte Ltd

Antimicrobial Surfaces

Both Cu and Ag nanoparticles have antimicrobial properties on the surface and when integrated into surgical instruments, like breathing tubes. Cu nanoparticles showed a Log-8 kill rate for E. Coli when deposited on a wound dressing.

Life Science Applications of the NL50 Nanoparticle Deposition System

Image Credit: Nikalyte Ltd

Drug Delivery

Compared to traditional treatments, capped Au nanoparticles deliver cancer treatment to specific sites at a lower dosage for the patient.

Bio Imaging

Magnetic nanoparticles and Au nanoparticles are used as markers for photoacoustic treatment, diagnostics and cancer imaging.

Photothermal Therapy

Targeted therapies are achieved by directly exciting the nanoparticles placed inside the body.

Environmental Science

Analysis of nanoparticle toxicity to marine life and the environment.

 

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