The Force Measurement module of the PALM RoboSoftware enables the quantitative
measurement of the forces of microscopic specimens with the PALM MicroTweezers
from Carl Zeiss. The new
module allows users in the fields of life sciences, materials sciences and pharmacy
to measure cell elasticity, molecular binding properties or plasma membrane
features of biological specimens, for example.
The intuitive and flexible user interface ensures easy operation of the Force
Measurement module. Users can define their own test configurations, i.e. the
software guarantees high freedom of experimentation. The module also enables
the use of the PALM MicroTweezers system for pure specimen manipulation as well
as for position detection and quantitative force measurement so that direct
comparisons of the measuring results with data from trade literature are now
possible. Various calibration routines for the characterization of the optical
tweezers are performed and evaluated automatically at the push of a button.
All relevant data and images are stored to completely document each experiment
and each calibration procedure. The module visualizes the measuring data in
Because the Force Measurement module requires no additional hardware, time-consuming
adjustment and calibration are a thing of the past. The FM StarterKit that comes
with the software module contains the FluidCell component, which permits fast
and easy sample preparation, particularly for force measurement experiments.
PALM MicroTweezers and the Force Measurement module can be combined with various
solutions from Carl Zeiss such as the PALM MicroBeam or Colibri.