Rigaku Americas Corporation is pleased to announce that the company has entered into an agreement with TTP LabTech (Royston, UK) to offer the mosquito nanolitre pipetting system as part of the Rigaku CrystalMation™ platform for automated protein crystallization experiments. As used by the pharmaceutical industry for rational drug design, the mosquito technology will be implemented on a custom basis for customers doing high-throughput research on membrane proteins, as well as RNA and DNA research.
TTP LabTech's mosquito is widely used for automated crystallography throughout the world. The mosquito has disposable, positive displacement pipettes, which ensure zero cross contamination, and the instrument can accurately aspirate and dispense a wide range of liquid types and viscosities. Mosquito's precise linear drives and optical sensors achieve positional accuracy better than 0.05 mm in the X, Y and Z axes. This, along with the tightly toleranced and relatively short pipette tips, allows drops to be placed with a high degree of accuracy in the center of sub-wells in crystallography-specific microplates or onto hanging drop membranes.
Specifically engineered to meet demanding objectives, the Rigaku CrystalMation system consists of banks of the Rigaku Minstrel™ HT imaging instruments, each coupled to up to two Rigaku Gallery™ 700 incubators. These incubators, operating at either ambient temperature or down to 4°C, are integrated by a central Rigaku Integration Module™. Complete liquid handling, for both screen makeup and protein dispense, are automated using the respective Rigaku Alchemist™ II, Phoenix™ RE and TTP LabTech mosquito modules in conjunction with robotic plate sealer stations. CrystalTrak, an Oracle™ based database application, forms the software backbone for designing, capturing, and analyzing crystallization experiments.
Since its inception in Japan in 1951, Rigaku has been at the forefront of analytical and industrial instrumentation technology. Rigaku and its subsidiaries form a global group focused on life sciences and general purpose analytical instrumentation. With hundreds of major innovations to their credit, Rigaku companies are world leaders in the fields of small molecule and protein crystallography, X-ray spectrometry and diffraction, X-ray optics, as well as semiconductor metrology. Rigaku employs over 1,100 people in the manufacture and support of its analytical equipment. Its products are in use in more than 70 countries—supporting research, development, and quality assurance activities. Throughout the world, Rigaku continuously promotes partnerships, dialog, and innovation within the global scientific and industrial community.