Water Vapor Sorption by Active Pharmaceutical Ingredients

The ability of active pharmaceutical ingredients (API’s) and their inactive carriers and fillers (excipients) to adsorb water is of fundamental interest in the pharmaceutical industry. Control of this property can have a significant impact on the shelf life of the product as well as its ability to be assimilated in the body. The degree and rate of water sorption can be influenced by encapsulation, controlling particle size, and changing the degree of crystallinity. Control of these processes is critical in producing a consistent product.

By varying the relative humidity (RH) under controlled conditions we can determine the RH at which adsorption is initiated, the rate of adsorption, and the amount of water adsorbed by the sample.

Which Instrument is Used?

The moisture sorption behavior of pharmaceuticals is quickly and conveniently measured by dynamic gravimetric water vapor sorption, often referred to simply as DVS. The Aquadyne DVS1 and Aquadyne DVS2-HT, available with optional 21 CFR Part 11 capable software, are suitable for characterizing these materials in the pharmaceutical industry through simple automated analyses.

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This information has been sourced, reviewed and adapted from materials provided by Quantachrome Instruments.

For more information on this source, please visit Quantachrome Instruments.

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