Posted in | News | Microscopy

Z-Axis Nanopositioning System with Extended Positioning Range by PI (Physik Instrumente)

High precision positioning of microscope objectives along the optical axis has just made a giant leap forward: While piezo actuation has always been the undisputed choice in optical positioning when dynamics and accuracy matter most, some applications could have benefitted from more travel range.

A new design principle developed by PI (Physik Instrumente) now extends the positioning range to 2 mm while maintaining very short settling times on the order of 20 milliseconds.


Optical metrology, super-resolution microscopy and other techniques require the nanometer and sub-nanometer level resolution and millisecond response provided by piezo nanopositioning devices. Until now, travel ranges of a few 100 microns were available, enough for most microscopy applications. PI’s new drive principle based on a coordinated motion of multiple piezo elements overcomes these limitations.  Deep penetration microscopy methods, such as two-photon microscopy, benefit from the new piezo positioning device.

Please access the datasheet on the optics positioner for further information.


High resolution microscopy methods, such as two-photon microscopy, make it possible to record 3D stacks with up to 1 mm depth in biological samples. Here conventional piezo techniques have posed a limitation. PI’s N-725 piezo-motor objective positioner and scanner breaks with conventional wisdom and helps exploit the new possibilities.

N-725 Z-Axis Positioner/Optical Axis Nanopositioning System.

Patented PiezoWalk Motor

Based on a patented piezowalk motor, the N-725 provides travel ranges of up to 2 mm along the optical axis to quickly and precisely change the focal plane. Despite its small size, the new device replaces and combines the performance of two individual stages: a fine focus piezo drive and a stepper motor positioner for coarse, long travel motion.

The challenge was to implement the high-stiffness piezo motor in a compact mechanical housing no larger than PI’s previous piezo-flexure-actuator based PIFOC® objective stages providing travel ranges from 0.1 to 0.4 mm. The new long-travel piezo motor provides 5 to 20 times the travel range, sub-nanometer resolution and locks into a position, without further need for power, significantly improving long term stability.

Controller and Software

The piezo-z-focus drive comes complete with a powerful motion controller and software. It is compatible with leading microscope imaging suite software packages.

About PI

The PI group provides the broadest and deepest portfolio of ultra-precision motion technologies, for markets as diverse as semiconductor manufacturing, bio-technology, photonics, aerospace and medical engineering. PI has 4 decades of experience with the design and manufacture of precision positioning systems based on piezoceramic and electromagnetic drives. The company has been ISO 9001 certified since 1994 and provides innovative, high-quality solutions for OEM and research. PI is present worldwide with 10 subsidiaries, R&D/engineering on 3 continents and total staff of 750+.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    PI (Physik Instrumente) LP. (2019, February 11). Z-Axis Nanopositioning System with Extended Positioning Range by PI (Physik Instrumente). AZoNano. Retrieved on April 20, 2024 from

  • MLA

    PI (Physik Instrumente) LP. "Z-Axis Nanopositioning System with Extended Positioning Range by PI (Physik Instrumente)". AZoNano. 20 April 2024. <>.

  • Chicago

    PI (Physik Instrumente) LP. "Z-Axis Nanopositioning System with Extended Positioning Range by PI (Physik Instrumente)". AZoNano. (accessed April 20, 2024).

  • Harvard

    PI (Physik Instrumente) LP. 2019. Z-Axis Nanopositioning System with Extended Positioning Range by PI (Physik Instrumente). AZoNano, viewed 20 April 2024,

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.