Researchers developed NMm@MINO, a minocycline-loaded gelatin nanoparticle coated with hybrid neutrophil–macrophage membranes to tackle bacterial infection, inflammation, and periodontal tissue damage. In laboratory and rat experiments, the platform killed bacteria, altered inflammatory responses, promoted osteogenesis-associated processes, suppressed osteoclast activity, and reduced alveolar bone loss.
Researchers developed glutathione-responsive EONPs that co-deliver STING and DHODH inhibitors to reprogram macrophage inflammatory metabolism in experimental sepsis. In mouse models, the treatment reduced inflammation and organ injury, improved short-term survival, and altered gut microbial metabolism, with 5-HIAA contributing to the immune response.
Researchers developed diimmonium DB·2X nano-agents that support photoacoustic imaging at 1700 nm, with DB·2TFSI showing strong performance in preclinical imaging experiments. In mouse models, 1700 nm imaging reduced endogenous background interference and improved signal-to-background ratios compared with 1064 nm, supporting further investigation of NIR-IIb photoacoustic contrast agents.
Researchers developed a rapid, one-pot method that used sunlight and a commercial vincristine formulation to form gold nanoparticles within five minutes without separate reducing or stabilizing agents. The particles retained vincristine’s antiproliferative activity against Colo-205 colon cancer cells and showed greater DPPH radical scavenging than free vincristine at several tested concentrations, while questions about drug photostability, release, stability, and in vivo performance remain.
Researchers engineered hybrid strontium sulfite nanoparticle-modified lipid nanoparticles to deliver p53 mRNA, producing higher reporter-gene expression, higher p53 transcript levels, and greater apoptosis in breast cancer cells than conventional LNPs. In mice, the p53 mRNA-loaded hybrid carrier slowed 4T1 tumor growth, although the study was small and preclinical, and the clearest biodistribution advantage appeared after PEGylation.
Researchers developed eggshell membrane-supported zinc oxide nanocomposites and found that the thermally synthesized formulation provided the strongest sperm cryoprotection and antimicrobial activity in laboratory tests, including semen from 120 men. In rats, it was associated with changes in reproductive, renal, and tissue measures, but the study did not demonstrate improved fertility through mating or establish a clinical treatment.
Researchers developed a sacrificial-template porous silica thin film for electrochemically directed oligonucleotide synthesis that increased the available reaction area while preserving localized electrochemical control. The platform supported parallel synthesis of 121-nucleotide strands and recovery of an encoded 60-byte message, while highlighting remaining challenges in synthesis fidelity, parallelism, and cost.
Researchers developed a target-responsive tetrahedral DNA nanoprobe that switches on fluorescence when it detects tumor-associated nucleolin or microRNA-21. In cell and mouse experiments, the probe enabled tumor imaging and fluorescence-guided surgery, although its safety, accuracy, and clinical value still require further testing.
A systematic review of 25 studies found that green-synthesized nanoparticles can improve the antimicrobial and mechanical performance of glass ionomer cements, and some formulations also support fluoride release. The evidence came from 24 laboratory studies and one animal study, with no human clinical trials, so long-term safety and clinical effectiveness remain uncertain.
The review examines how engineered nanoparticles and predictive tools, including PK/PD, PBPK, CFD, and AI/ML models, could improve drug delivery across the blood-brain barrier for Alzheimer’s, Parkinson’s, and Huntington’s diseases. It also identifies major barriers to clinical use, including low brain accumulation, long-term safety concerns, model validation, and differences between animal and human biology.
Terms
While we only use edited and approved content for Azthena
answers, it may on occasions provide incorrect responses.
Please confirm any data provided with the related suppliers or
authors. We do not provide medical advice, if you search for
medical information you must always consult a medical
professional before acting on any information provided.
Your questions, but not your email details will be shared with
OpenAI and retained for 30 days in accordance with their
privacy principles.
Please do not ask questions that use sensitive or confidential
information.
Read the full Terms & Conditions.