Nabsys will present data from solid-state nanodetectors at the Omics and Personalized Medicine Conference to be conducted from February 16 to 18, 2012, at the European Molecular Biology Laboratory in Heidelberg, Germany, and at the annual meeting of Advances in Genome Biology and Technology to be conducted from February 15 to 18, 2012 in Marco Island, Florida.
The data demonstrates the first direct electronic mapping and re-sequencing of DNA. Unlike nanopore sequencing, Nabsys’ positional sequencing platform does not try to differentiate single nucleotide bases moving across an electrical detector. Instead, the method hybridizes short oligonucleotide probes into very long DNA templates, passes the probe-bound templates via solid-state nanodetectors and electronically detects the hybridized probe locations. By gathering data on several hybridized probe locations, comprehensive genomic maps can be created with sparse probe coverage or true de novo large genome sequences with dense probe coverage.
The positional sequencing platform provides data about both the location and identity of DNA sequences via direct electrical detection of probes attached to individual molecules, which may be large molecules with a length of hundreds of kb. Based on the deployment of a methodology, the platform can be utilized to investigate the entire size scale of DNA variation that includes chromosomal aneuploidies, large scale genomic structural variants and single-base resolved sequence.
In the positional sequencing platform, DNA translocation rates are not slowed down through nanodetectors, thus producing data quickly over unprecedented length scales. The solid-state nanodetectors are the basis for the highly scalable platform that is capable of drastically decreasing data burden and improving throughput, and also proves useful in mass production.
During the presentations, the company will demonstrate its DNA preparation techniques and design of nanodetectors.
Source: http://www.nabsys.com/