NanoSight, leading manufacturers of unique
nanoparticle characterization technology, reports on the breakthrough
cancer metastasis research of Dr. Hector Peinado Selgas and Dr. David
Lyden's research team from Weill Cornell Medical College.
Lead study author Dr. Peinado, Instructor of Molecular Biology in
the Department of Pediatrics at Weill Cornell, describes in his recent
published research work in Nature Medicine with senior author Dr.
Lyden's research group how they were able to gain better understanding
and characterization of exosomes, secreted nanoparticles from tumor
Dr Hector Peinado Selgas using his NanoSight LM-10 system at Weill Cornell Medical College, New York
"In our laboratory, we are interested in analyzing the role of
tumor-secreted exosomes in metastasis. We have recently published a
study describing how exosomes secreted from melanoma tumor cells are
educating bone marrow derived progenitor cells toward a pro-metastatic
phenotype. We are also interested in analyzing the use of exosomes as
biomarkers of specific tumor types and their use as prognostic factors,
on which Cornell University currently has pending patents on this
"We have found that the protein content per exosome is increased in
metastatic melanoma patients. In addition, we have observed that
metastatic cell lines also have increased protein content per exosome.
Therefore, knowing the number of exosomes was a definitive and
necessary step in our reseach. Before this work, we were only following
qualitative changes in exosomes. Now we are able to make quantitative
analyses using Nanoparticle Tracking Analysis technology. This has
faciliated our recent research work."
"Prior to using NTA, I was measuring exosome size by electron
microscopy. There was no other technique available. The new technology
allows us to analyze millions of particles, particle by particle, in
minutes giving not only numbers but also population distribution.
Although the measurement of the size of the particles is not as
accurate as the electron microscopy, NTA does allow us to process a
large number of samples in a short time period."
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characterization using the company's unique nanoparticle tracking
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