Malvern Product Development Manager to Present On-Line Nanoparticle Characterization at IFPAC 2015

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Malvern Panalytical’ Product Development Manager for Process Systems, Alon Vaisman, will be presenting two papers covering two very different analytical techniques and their applications at the 2015 Annual Meeting of the International Forum on Process Analytical Technology and Quality by Design (IFPAC).


Alon Vaisman, Product Development Manager for Process Systems at Malvern Panalytical


Vaisman's presentations will be part of the Particle Characterization session which will take place on the afternoon of Tuesday 27 January 2015.

IFPAC 2015 will take place in Arlington in the US state of Virginia. Vaisman’s presentations will cover the ‘Applications of Dynamic Light Scattering as PAT for on-line nano-particle characterization’ and ‘In-situ monitoring of high shear and fluid bed processing using spatial filter velocimetry’, which are currently two very popular topics within the pharmaceutical production industry.

Dynamic light scattering (DLS) is an important technique used in the particle sizing of proteins, colloids and dispersions. The observation of scattered light allows defining characteristics of a particle dispersion or molecular solution such as particle size, molecular weight and zeta potential to be determined.

The growing importance of large molecule based therapeutics and the drive to decrease the particulate size of small molecule APIs, is creating new challenges for in-process particle characterization.

Advances in process development and manufacturing control are being supported by the automation of dynamic light scattering (DLS) measurements coupled with the use of this equipment as a process analytical instrument.

Vaisman’s first topic will cover various examples of how on-line DLS can be applied to processes such as emulsification and nano-milling.

His second topic will consider the other end of the particle size spectrum and will analyse the application of PAT instruments based on spatial filter velocimetry for in-situ particle size testing within fluidized bed and high shear granulation methods during pharmaceutical production.

Simple, versatile dynamic light scattering system - Zetasizer Nano

Vaisman will also touch upon the application areas of the method to monitor coating layer thickness and how agglomeration during Wurster coating can be determined.

For further details on the sessions, please visit IFPAC’s website here.

Further details on the applications of both dynamic light scattering (Zetasizer) and spatial filter velocimetry (Parsum Probe) can be found on Malvern Panalytical’s website here.

About Malvern Panalytical

Malvern Panalytical provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries.

Used at all stages of research, development and manufacturing, Malvern Panalytical’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.

Headquartered in Malvern Panalytical, UK, Malvern Panalytical has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.

Alexander Chilton

Written by

Alexander Chilton

Alexander has a BSc in Physics from the University of Sheffield. After graduating, he spent two years working in Sheffield for a large UK-based law firm, before relocating back to the North West and joining the editorial team at AZoNetwork. Alexander is particularly interested in the history and philosophy of science, as well as science communication. Outside of work, Alexander can often be found at gigs, record shopping or watching Crewe Alexandra trying to avoid relegation to League Two.


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