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DOI : 10.2240/azojono0104

Nanotechnology and Developing Countries - Part 2: What Realities?

Donald C. Maclurcan

Submitted: June 28th, 2005
Posted: October 19th, 2005

Topics Covered

Abstract

Background

Assessing Global Engagement with Nanotechnology

Analysis of Data

Collating of Data

Excluded Data

Limitations of the Study

Global Nanotechnology Activity and Interest

Countries Actively Involved in Nanotechnology

Lesser Known Nanotechnology Players Encouraging Development

The Global Nanotechnology Race

Some Countries to Concentrate Nanotechnology Efforts on Materials Research

National Activity by Human Development Index

Is Nanotechnology R&D Feasible For Less-Developed Countries?

Challenges for Nanotechnology in Developing Countries

The Cost of Setting Up Nanotechnology Institutes

Facilitated Partnerships and Access to Information

European Commission Partnerships

Asia Pacific Partnerships

Partnerships for Countries in the Bottom Third of the HDI Rankings

Barriers to Global Partnerships

Scientific Publishing

Health-Related Nanotechnology Patent Activity

World Leaders in Nanotechnology Research

Health-Related Nanotechnology Development in China

Health-Related Nanotechnology Development in India

Distribution of Health-Related Patents by Continent

Patent Ownership by Sector

Assessing Patents by Utility

Patents Classified by Disease

Global Participation Nanotechnology Dialogue

China’s Absence from Discussions

Concerns for Some Developing Nations

Attempting to Address The Lack of Cohesion in Global Nanotechnology Policy

Conclusions

References

Contact Details

Abstract

Drawing on search-engine data gained from combining the term ‘nano*’ with the title of every economy recognised by the World Bank, the research to be described here highlights a widespread developing country engagement with nanotechnology research and development. Subsequent investigation reveals that the orientation of developing country engagement is distant from nanotechnology’s ‘social development’ applications, often cited as most applicable to developing countries. The ability of less-developed countries to engage with nanotechnology R&D is explored along with current mechanisms to facilitate partnerships and access to information. The additional analysis of health-related patents confirms that the ‘nano-divide’ is already here. With China constituting the bulk of patents from the South, the divide is not just between the developed and developing world, it extends to within the developing world. An assessment of participation in international nanotechnology policy and dialogue highlights low levels of developing country representation, supporting the overall argument that nanotechnology may be set to follow the path of past technologies in creating a greater global technological divide.

Background

Discussions concerning the potential implications of nanotechnology for developing countries have tended to be polarised. Whilst many see nanotechnology providing developing countries with an opportunity to promote sustainable development [1-5], others view the emerging area as an opportunity for increased exploitation of the developing world and concentration of power among corporate elites [6, Shiva, cited in, 7]. In a previous paper, we highlighted the need for discussions to show cognisance of historical trends and current barriers to technology distribution.

In 2003, Court et al. categorised 10 developing countries as either ‘front-runners’, ‘middle-ground’ or ‘up-and-comers’ with respect to nanotechnology activity [4]. Whilst their study highlighted a surprising level of developing country research and development (R&D) in nanotechnology, it fell short of assessing nanotechnology engagement amongst all developing countries. Early analyses of patent distribution have shown ownership concentration among a select group of countries, led strongly by the United States (U.S.), Germany and Japan [8] and strong private sector influence in patenting within the U.S. [9] but have limited their assessments to U.S. Patent and Trademark Office (USPTO) data. Whilst a number of researchers have made a point of highlighting the poor levels of participation by developing countries in international nanotechnology developments [4, 5, 10], there remains a need for some tangible assessment.

In this paper we present a synopsis of global engagement with respect to nanotechnology R&D, explore the orientation of developing country engagement, consider challenges to the creation of national nanotechnology capabilities for less-developed countries, analyse health-related nanotechnology patent activity and assess country participation in nanotechnology policy dialogue.

Assessing Global Engagement with Nanotechnology

Using the ‘Google’ and ‘Yahoo’ search-engines we individually combined the term ‘nano*’ with the title of every economy recognised by the World Bank in 2004a, aiming to provide an encompassing picture of nanotechnology activity, as of October 2004. We extended our search parameters to include countries demonstrating either an interest, current research, national activities or national funding in nanotechnology (as outlined in Figure 1). Countries registering activity were then categorised by the 2003 Organisation for Economic Development (OECD) and 2004 United Nations Development Program Human Development Index (HDI) classificationsb, to assess the distribution of engagement across recognised global groupings. Our classification did not distinguish the strength or research directions of each commitment.

Table 1. Categorisation of national nanotechnology activity

Category

Requirements To Fulfil The Category

National Activities or Funding

Either:

A national strategy for nanotechnology;

Nationally co-ordinated nanotechnology activities;

Government funding for nanotechnology research

Individual or Group Research Project

At least one individual or group currently conducting work identified as ‘nanotechnology research’

Country Interest

An expression of interest from country governments,  representatives or delegates

With patent data used in previous studies as a key indicator of country strength in nanotechnology R&D [11, 12] and the life sciences as one of the major fields of nanotechnology patenting [8], we decided to focus the second stage of our research upon health-related nanotechnology patent activityc. To do so we assessed data from 1975d – 2004, registered with the widely encompassing, European Patent Office (EPO) databasee.

Note:

a.       Available at: http://www.worldbank.org/data/aboutdata/errata03/class.pdf, (for the purposes of this paper, the term  ‘countries’ includes ‘territories’ recognised by the World Bank).

b.       In this paper countries are classified by the January 2003, OECD ‘DAC List of Aid Recipients’, available at: http://www.oecd.org/dataoecd/35/9/2488552.pdf. HDI data was not available for Serbia and Montenegro, Taiwan, Afghanistan, Puerto Rico and Liechtenstein.

c.       Considering that Rader notes comparability among U.S. and foreign success rates for obtaining patents from patent applications in biotechnology [13], we used both patent applications and assigned patents for our research in ‘patent activity’ and regularly interchanged the terms ‘patent activity’ and ‘patents’.

d.       1975 is used as the commencement date for the research as it was the year following that in which the word ‘nanotechnology’ was coined [14].

e.       The Espacenet database can be accessed at: http://ep.espacenet.com and incorporates published data from over 70 different countries.

Analysis of Data

Employing a ‘basic analysis’ and only registering distinct patents, we used the European Classification system (ECLA) to distinguish health-related areas on which to base our search for patents including the term ‘nano*’f. Noting some limitations of the ECLAg, we conducted a supplementary ‘title-search’h, combining the ten most common health-related terms identified in the ECLA search with the term ‘nano*’. This produced a further list of a 197 health-related terms, gained from the patent titles, that were run through an identical process to that of the initial search (see Table 2 for examples of searched classifications and terms).

Table 2. Classifications and terms used for health-related nanotechnology patent search

ECLA Classifications

Resultant Terms

Examples of Subsequent Terms

Medical or veterinary science; hygiene;  Foodstuffs; Water purification; Antibacterial paints

health*; medic*; disease*; diagnos*; detect*;

drug*;

delivery; therap*

cosmetic*; treat*

antibacterial; antiseptic; prescription; bone; prophylaxis; pharmaceutical; genetic; vaccine; targeted; vitamin; skin

Note:

f.        Based upon the data of Huang et al., 92.5% of the nanotechnology patents registered with the USPTO office between 1976-2003 included the term ‘nano*’ [8].

g.       For example, many Chinese Patents without an abstract could not be included in the ECLA but could be identified as health-related, via their title. Furthermore, it takes up to 8 months before 90% of ECLA data is confirmed [15] yet our study of 1975-2004 data concluded in May 2005.

h.       Known to give an adequate indication of patents without needing to conduct a full text search [8].

Collating of Data

The collated data was divided, based on the nationality of the patent holder(s), to give an idea of the national distribution of patents. The countries were then placed into developmental, continental and sectoral groupings to enable a broader assessment of patent distribution. Data was compared with Compañó and Hullman’s 2002 EPO and Patent Cooperation Treaty nanotechnology patent analysis [12].

Considering the claim that pharmaceutical giants are investing less money and people in nanotechnology than other industries [16], we felt it important to gauge the engagement from big pharmaceutical companies in health-related nanotechnology patenting. Hence, we recorded a list of the top 20 institutions patenting in this area. Due to implications of multiple holders for individually owned patents, private individuals were not included in the presented data.

In 2003, White noted that bio-nanotechnology patenting was occurring in three main areas: cosmetics and consumer health; instrumentation, focussed on general diagnostic processes; and drug delivery [17]. We therefore chose to include data on the strength of patenting within these three areas of utility.

Furthermore, with relatively little research directed towards some of the health problems affecting the majority of the world’s population, we chose to analyse every title and abstract for references to diseases in order to assess one aspect of early orientation within health-related nanotechnology research. Viruses and general conditions were deemed too broad to be included in this analysis.

Excluded Data

The patent research was made difficult by factors such as one Chinese national holding over 500 health-related nanotechnology patents “by simply turning traditional plants into fine powders with particles under 100 nanometres… and claiming a new invention” [18]. Such results were excluded.

Limitations of the Study

Both the first and second stages of our research suffered from the limitation that classifying research as ‘nanotechnology’ has only been a recent phenomenon. Much work that occurs on the nanoscale is not referred to as ‘nanotechnology’ and therefore may not have been registered by our research methods. In stark contrast, it is possible that a number of individuals and companies incorrectly use the term ‘nano’ in the title of their work, perhaps hoping to gain from the hype surrounding nanotechnology.

The final stage of the research assessed country participation at two, key, recent international nanotechnology meetings. These were the International Dialogue on Responsible Research and Development of Nanotechnologyi held in 2004, which was the first intergovernmental dialogue of its kind, and the North–Southj Dialogue on Nanotechnology: Challenges and Opportunitiesk held in 2005, which was the first United Nations-sponsored meeting held to specifically address developing country participation in nanotechnology science and policy. As with earlier stages, categorisation occurred on a country level and used the 2003 OECD classifications. As the discussion will suggest, participation in the development of global nanotechnology policy and strategies extends well beyond representation at international conferences and meetings. Furthermore, the data limited participant assessment to one’s nationality, leaving issues such as gender equity as important areas for future research.

Note:

i.         The meeting report may be found at: http://www.nanoandthepoor.org Final_Report_Responsible_Nanotech_RD_040812.pdf.

j.        In this paper, the term: ‘South’ or ‘Southern’ is used to refer to developing countries, whilst the term: ‘North’ or ‘Northern’ is used to refer to developed countries.

k.       See http://www.ics.trieste.it/Nanotechnology/ for more details.

Global Nanotechnology Activity and Interest

In 2001 the U.S. NSF claimed that at least 30 countries had initiated, or were beginning, national nanotechnology activities [19]. This figure progressed to, “more than 40”, by 2004 [8]. According to our research, this number has grown to 62 countries, 18 of them ‘transitional’ and 19  ‘developing’, engaging with nanotechnology on a national level. A further 16 countries demonstrate either individual or group research in nanotechnology, 3 of which are ‘transitional’ and 12 ‘developing’ (including 1 Least Developed Country (LDC)). Fourteen countries have expressed interest in engaging in nanotechnology research. Of these countries, 1 is ‘transitional’ and 13 ‘developing’, including 3 LDCs (for a full, country breakdown see Table 3).

Table 3. Global distribution of nanotechnology activity by country and classification.

Least Developed

Other: Developing

Transitional

Developed

National Activity or Funding

 

Argentina; Armenia; Brazil; Chile; China; Cost Rica; Egypt; Georgia; India; Iran; Mexico; Malaysia; Philippines; Serbia & Montenegro; South Africa, Thailand, Turkey; Uruguay; Vietnam

Belarus; Bulgaria; Cyprus; Czech Republic; Estonia; Hong Kong; Hungary; Israel; Latvia; Lithuania; Poland, Romania; Russian Federation; Singapore; Slovak Republic; Slovenia; South Korea; Ukraine

Australia; Austria; Belgium; Canada; Denmark; Finland; France; Germany; Greece; Iceland; Ireland; Italy; Japan; Luxembourg; Netherlands; New Zealand; Norway; Portugal; Puerto Rico; Spain; Sweden; Switzerland; Taiwan; United Kingdom; United States of America

Individual or Group Research

Bangladesh

Botswana; Columbia; Croatia; Cuba; Indonesia; Jordan; Kazakhstan; Moldova; Pakistan; Uzbekistan; Venezuela

Macau, (China); Malta; United Arab Emirates

Liechtenstein

Country Interest

Afghanistan; Senegal; Tanzania

Albania; Bosnia and Herzegovina; Ecuador; Ghana; Kenya; Lebanon; Macedonia; Sri Lanka; Swaziland; Zimbabwe

Brunei Darussalam

 

The most prominent figure is the number of countries engaging in nanotechnology on a national level at such an early stage of global development. Although every developed country, excluding Liechtenstein, is included in this category, the large number of developing countries is of note.

Countries Actively Involved in Nanotechnology

In China, nationally run activities in nanotechnology have existed since 1990 [20, 21] and the country “appears to be leading the world in sheer numbers of new nanotechnology companies” [22]. Brazil has approximately 300 Ph.D.-level researchers working in nanotechnology [23], whilst in India more than 30 institutions are involved in research and training programs in nanotechnology [24]. Vietnam commenced nanotechnology research in 1992 [25] and the Ministry of Science and Technology has launched a nanoscience and nanotechnology infrastructure building program from 2004-2006 [26]. In 2004, 117 participants came from all over Thailand to contribute to the development of a national nanotechnology roadmap [27]. In 2003, Maruping reported that South Africa had approximately 12 universities, 4 science councils and several companies active in nanotechnology R&D [Maruping, cited in 5]. In 2003, at least 6 groups were working on nanotechnology in the Philippines [28]. Whilst Malaysia has 6 existing research centres engaging in nanotechnology research [29].

Lesser Known Nanotechnology Players Encouraging Development

In 2004, Egypt, Bangladesh and Moldova were among some of the lesser known nanotechnology ‘players’ to host international nanotechnology conferencesl, perhaps as a precursor to a greater involvement in nanotechnology R&D. The International Conference on Nanotechnology: Science and Application, held in Egypt the following year, was pitched at developing country involvement and exposing young researchers from the developing world to leading researchers in the fieldm.

Note:

l.         See: www.nanotech-now.com/2004-events.htm for a list of nanotechnology conferences held in 2004 and their locations.

m.     See: http://www.nanoinsight.net/ for conference details.

The Global Nanotechnology Race

Could nanotechnology promote a more equitable engagement with global science? In 1999, before the establishment of the National Nanotechnology Initiative in the U.S., Roco wrote that “the situation is unlike the other post-war technological revolutions, where the U.S. enjoyed earlier advances”. A recent report by the U.S. President’s Council of Advisors on Science and Technology has shown that the U.S. leads the world in the number of nanotechnology start-up companies and research output but “…is under increasing competitive pressure from other nations…” [30]. Furthermore, Haworth believes that “no one country or region of the world has a monopoly on the cutting-edge research capabilities necessary to advance materials science and nanotechnology” [Haworth cited in 31 preface]. Watanbe claims that the widespread interest is resulting in countries “…competing on a more equal basis for a slice of the action” [32].

However, Runge and Ryan note that, despite developing countries making up more than half of the 63 countries engaged in biotechnology R&D, innovation remains heavily concentrated amongst the top 5 countries, with a significant gap to the ‘2nd tier’ [33]. Whilst global government spending on nanotechnology is relatively evenly split between North America ($1.6 billion), Asia ($1.6 billion) and Europe ($1.3 billion)n [30], funding among nations varies greatly. For example, whilst both the U.S. and Thailand have national nanotechnology programs, established in 2000 and 2003, respectively, Thailand’s program receives approximately $2 milliono per year [34] compared with 2005 annual funding for the U.S. National Nanotechnology Initiative (NNI), set at $982 million [35].

Furthermore, widespread national engagement with new technology does not necessarily translate to an automatic ‘trickle-down effect’ of associated benefits. As Chrispeels notes, with the ‘Green Revolution’p, “many governments (national or local) did not do enough to ensure an even spread of the benefits among the different types of farmers and the different socio-economic groups” [36].

Note:

n.       The Lux Research data included U.S. State funding in the total for North America and incorporated figures from associated and acceding EU countries in the European estimate. The remaining governments, not covered above, contributed $133 million.

o.       All monetary figures in this paper refer to U.S. dollars.

p.       A movement commencing in the 1940s that focused on increasing crop yields via the application of new plant varieties and modern agricultural techniques.

Some Countries to Concentrate Nanotechnology Efforts on Materials Research

Whilst most of the international commentary on the relevance of nanotechnology to developing countries has focussed on applications to assist sustainable development in social development cluster areasq, Chinese, South Korean, Malaysian and Thai governments will reportedly focus 2003-2007 nanotechnology funding on materials research [22]. In Thailand the initial focus has been on applying nanotechnology to ‘value-add’ to existing export industries and develop: waterproof, more durable silks; ‘smart packaging’ to monitor and maintain the state of food; more productive wine fermentation; ‘self-sterilising’ rubber gloves; and new car body materials [34]. With this in mind, Barker et al. suggest that “most government investments are aimed at improving national corporate competitiveness in nanotechnology” [5]. Roco believes some governments are focussing efforts towards nanotechnology because they have recognised lost opportunities at the dawn of earlier technologies such as the Human Genome Project, ICT and biotechnology [19].

Note:

q.       According to the South African Nanotechnology Initiative, nanotechnology sectors can be classified into ‘industrial’ and ‘social development’, with the latter incorporating: energy; water; and health. ‘The environment’ crosses both sectors [37].

National Activity by Human Development Index

An assessment of national activity by HDI groupings (Figure 1) shows that the strength of developing country engagement with nanotechnology comes from countries with a medium HDI rank. China, India and Brazil lead developing country investment in nanotechnology [Rao, cited in 38], ahead of many developing countries with a higher HDI rank.

AZoNano - Nanotechnology - Global distribution of nanotechnology activity based on countries’ human development groupings.

Figure 1. Global distribution of nanotechnology activity based on countries’ human development groupings.

So what about the less-developed countries? It is clear that countries in the lowest bracket of either the OECD classifications or HDI rankings, have not engaged with nanotechnology on any significant level. Will this revolution promote a bigger South-South divide, whereby certain developing countries use nanotechnology to propel themselves into global trade and investment markets whilst others are left behind?

Is Nanotechnology R&D Feasible For Less-Developed Countries?

Whilst factors such as support from private enterprise will play a significant role in determining the level of nanotechnology engagement in a countries such as India or Thailand [27, 39], for many of the less-developed countries, the current barriers will present themselves at the earliest stages of R&D entry.

Challenges for Nanotechnology in Developing Countries

The correlation between lower average incomes and lower government spending on R&D [40] and healthcare [41], presents an initial challenge for nanotechnology to even be considered in less-developed countries. Infrastructure; human and policy capacity; cost; intellectual property rights; education relating to academics and the public; brain drain; trade barriers and the political context, constitute further barriers, although these are not unique to nanotechnology [42].

The Cost of Setting Up Nanotechnology Institutes

Differing figures have been provided as to the financial and infrastructure demands of nanotechnology innovation. The cost of establishing nanotechnology institutes has been claimed at approximately $5 million in both Vietnam [43] and Mexico [Rao, cited in 38], whereas the new national nanotechnology facility in Costa Rica, including a ‘clean room’, was reportedly built for “about $50,000”, and will be equipped for an extra several hundred-thousand dollars [44]. Rao claims an Atomic Force Microscope, a fundamental tool for characterisation at the nanoscale, costs approximately $1.5 million [Rao, cited in 45], whereas the ETC Group puts this figure at $175,000 [42]. Salvarezza believes that the ability for nanotechnology research to be conducted with relatively inexpensive items such as computers and scanning probe microscopes means that it “becomes an attractive field for research and development in third world countries because it can be done with modest resources and relatively low funding” [46]. Furthermore, Welland challenges the contemporary belief that drug research has to be capital intensive, claiming that pocket-sized, drug factories “could theoretically end the control of large companies over manufacturing” [Welland cited in 47]. On the other hand, Waga believe that as scientists work with matter on a smaller scale approaching the nanoscale, more sophisticated and expensive equipment is required [48].

As with most emerging technology, one cannot generalise about nanotechnology innovation being ‘expensive’ or ‘inexpensive’. Rather, nanotechnology innovation encompasses a wide spectrum of R&D activity, from less sophisticated powders all the way through to highly complex quantum computers. Existing resources, niche areas for development and program aims will all play a role in any countries’ national assessment prior to engaging with nanotechnology R&D.

Facilitated Partnerships and Access to Information

Partnerships between countries are crucial for successful developing country engagement with nanotechnology. The U.S. NSF suggests that there is scope for ‘win-win’ in the pre-competitive stages of international nanotechnology R&D [31], although this acknowledges, in part, that the situation becomes ‘zero-sum’ when the research moves to the commercialisation stage. The NSF also sees ground for leveraging investments and educating young investigators [31] and that “research groups in different countries and regions can bring complementary expertise to solve common problems for the ultimate benefit of society as a whole” [Haworth in 31 preface]. In 2002, the NSF had already developed partnerships with India and the Asia Pacific Economic Cooperation group [31] and, since then, has been integral in the development of national nanotechnology initiatives in Vietnam and Costa Rica [44, 48].

European Commission Partnerships

Similarly, the European Commission (EC), believing “a wider critical mass is beneficial” [49], has encouraged widespread participation in nanotechnology. In promoting their Sixth Framework Programme, the EC highlighted the possibility of funding for developing country nanotechnology projects [49]. Simultaneously, the EC negotiated bilateral nanotechnology partnerships with Argentina, India, Chile, China, Russia and South Africa [50].

Asia Pacific Partnerships

Regional partnerships in the Asia Pacific are meeting with some success for developing countries. The Asia Nano Forum involves 13 countries including China, India, Hong Kong, Singapore, Thailand, South Korea, Indonesia, Malaysia and Vietnam. Similarly, the APNF offers opportunities for Asian countries to engage in dialogue on collaboration and has already held international nanotechnology meetings on issues as widespread as human resources development and environmental protection and pollution.

Partnerships for Countries in the Bottom Third of the HDI Rankings

Apart from South Africa and India, we have found no evidence to suggest any official R&D partnerships including countries in the bottom third of the HDI rankings. Yet, with nanotechnology research underway in Pakistan, Bangladesh and Botswana and expressions of interest from Kenya, Senegal, Swaziland, Ghana, Tanzania and Afghanistan concerning an engagement with nanotechnology, the opportunity exists for nanotechnology partnerships to promote emerging science in some of the less-developed countries. In Africa, where nanotechnology research “has been largely academic and disparate” [51], regional partnerships and pooling of resources, both virtual and physical, may offer geographical and cultural advantages over trans-continental partnerships and present the operative strategy for African engagement in nanotechnology R&D.

In 2003 the World Bank provided $1/4 million for a ‘nano science and technology observatory’ as part of the Brazilian Millennium Institute in nanotechnology [52]. However, noting the inappropriateness of a ‘developed world model’ for nanotechnology innovation in developing countries [39, 53], caution must be taken to ensure nanotechnology is not viewed as a means by which developing countries are to replicate the development path of the industrialised nations. Such understanding was demonstrated at the UNIDO-sponsored, ‘2004 Technology Fair of the Future’. This event incorporated nanotechnology and “allowed least developed countries to present their technology needs, to identify mechanisms to match needs and trends and to determine their potential role in global value chains” [54].

Barriers to Global Partnerships

One barrier to global partnership is that clear information concerning national nanotechnology activity and global resources, remains unavailable or beyond the access capability of many. Reports outlining international activity in nanotechnology, such as the ‘Lux Report’, currently cost in excess of $4500r. The Global Nanotechnology Network, formed out of the 2001 ‘Workshop on International Collaboration and Networking’, seeks to address this situation by facilitating information exchange, collaborations and access to critical resources in the field of nanotechnology [55].

Note:

r.        See: https://www.globalsalespartners.com/lux/order.asp?retrysecure=1 for cost details.

Scientific Publishing

With scientific journals becoming increasingly unaffordable for developing countries [56], examples such as the online AzoNano Journal of Nanotechnology offer a unique and important step towards open-access information in cutting-edge science, technology and policy, via financial incentives for authors and reviewers. The associated websites provides a free database for many issues and research papers related to nanotechnology. Another site, managed by SciDev.nett, offers efficient, free access to nanotechnology updates compiled by some of its 300 researchers posted around the world. This group has agreements with some of the most prestigious journals, such as Science, allowing them to post articles on their site, free of charge.

Electronic education offers one avenue to bridge the gap between differing academic expertise internationally [57], particularly those that have a growing ICT infrastructure and reasonably inexpensive bandwidth costs. In 2004, Dr Joe Shapter from Flinders University, in Australia, conducted an Internet link-up between Australia and New Zealand, hosting an online, real-time nanotechnology demonstration involving the use of atomic force microscopy. This opens the way for an interactive, online method of international training for teachers in countries lacking such expertise [58].

Note:

s.       www.azonano.com.

t.        www.scidev.net

Health-Related Nanotechnology Patent Activity

Our assessment of health-related nanotechnology patents registered 1256 distinct results, showing that 35 countries have a share in the global distribution (as shown in Figure 2). The three leading countries are the U.S. (32.8%), China (20.3%) and Germany (12.9%), with the top 7 countries holding 88% of the overall patent share. Compañó and Hullman’s study of general nanotechnology patents from 1991-99 shows a similar concentration among the top 7 country holders (92.1%) [12]. However, unlike their study where the only transitional or developing countries ranking in the top 15 holders were Israel and Russia [12], our research showed that in health-related nanotechnology, patent participation extends to the transitional countries of South Korea (3.9%), Israel (0.9%), Russia (0.5%), Taiwan (0.3%), the British Virgin Islands (0.2%), Hong Kong (0.2%), Hungary (0.2%), Poland (0.2%), Singapore (0.2%), Bermuda (0.1%) and Slovenia (0.1%). Furthermore, developing country patent holders include China (20.3%), India (0.5%), Brazil (0.1%), and Serbia and Montenegro (0.1%).

AZoNano - Nanotechnology - Distribution of health-related nanotechnology patent activity (1975-2004), by country.

Figure 2. Distribution of health-related nanotechnology patent activity (1975-2004), by country.

World Leaders in Nanotechnology Research

Whilst commentators have suggested that the U.S. “does not dominate nanotechnology research” [31] or “…have a commanding lead as it was for other S&T (science and technology) megatrends” [59], it would appear that the U.S. has a very strong position in health-related nanotechnology. However, the 2004 data shows China catching up to the U.S. in health-related nanotechnology patenting, with 123 patents, compared with 128 for the U.S. Third placed Germany produced 39 patents (See Figure 3).

AZoNano - Nanotechnology - 2004 Distribution of health-related nanotechnology patent activity by country.

Figure 3. 2004 Distribution of health-related nanotechnology patent activity by country.

Health-Related Nanotechnology Development in China

Challenging a 2003 report that stated Chinese domestic studies in biomedicine lagged behind those in developed countries [60], the present data suggests that China will use health-related nanotechnology to leverage its position in the 21st century knowledge economy. The strength of China’s patenting defies the general statistic that less than 2 per cent of all the world’s patents are granted to scientists in the South [6] but obscures weak levels of patenting among the other developing countries.

Health-Related Nanotechnology Development in India

With India touted as “likely to become a leader in nano technology within the next five to ten years” [Pillai, cited in 61], the country remains behind the rest of the world by about 6 years in nanotech patenting [Sastry, cited in 45]. Yet these results come at a time of great transition for developing country patent regimes in light of required accession to the Trade Related Aspects of Intellectual Property Rights Agreement. Furthermore, Indian research has been strengthened by a number of domestically-based, international nanotechnology healthcare conferences. In both 2003 and 2005, an international workshop on ‘Nanotechnology and Healthcare’ saw a wide range of researchers and industry professionals, including Nobel laureates, gather in India to discuss applications of nanotechnology in frontier areasu. These conferences flanked ‘The First World Congress on Nano-biotechnology’ in 2004, and “Nanobiotechnology: Implications on Food, Health and Nutrition Security”, in 2005.

Note:

u.       See http://www.sastra.edu/nthc/ for more details.

Distribution of Health-Related Patents by Continent

When we look at the distribution of health-related patents, by continent (shown in Figure 4), we see little separating Europe (36.7%), North America (34.2%) and Asia (28.8%). The large involvement of Asia suggests that nanotechnology may be the first widespread technology in which Asian countries have a foundational role. Competition, arising from a relatively evenly distribution of patents across the three continents will probably lead to a more rapid development of nanotechnology but may do little for partnership outside these regions. Few or no patents are held in Oceania (0.2%) South America (0.1%) and Africa (0%). This furthers our earlier claims that a ‘nano-divide’ may exist within the developing world highlighting the continental divide in health-related nanotechnology patenting.

AZoNano - Nanotechnology - Global distribution of nanotechnology health-related patent share, by region.

Figure 4. Global distribution of nanotechnology health-related patent share, by region.

Patent Ownership by Sector

With respect to sectoral ownership, 77% of patents are held privately, 16% by universities, 5% by government and 2% by independent, not-for-profit organisations (outlined in Table 4).

Table 4. Distribution of health-related nanotechnology patent activity, by sectors.

Sector

Share (%)

Private
Company
Individual


54
23

University

16

Government

5

Independent, Not-For-Profit

2

This data is consistent with the belief that “independent public research is becoming extinct” [6]. As Chrispeels notes, research contributing to the Green Revolution was conducted in the public domain and included free distribution of resultant technologies, “without concerns for the intellectual property rights of those who produced them” [36]. However, in the 21st century there is an increasing difficulty of public sector researchers to access technologies to fulfil their missions [62].

The top 20 holders account for 28% of the patents (Comprehensive data is shown in Table 5), with the top 10 institutions holding 22% of the total. The difference here, as compared with biotechnology, is that many of these are multinational corporations (MNCs), engaging right from the ‘beginning’ [63].

Table 5. Top 20 institutions with health-related nanotechnology patent activity.

Rank

Top 20 Institutions

Patents

Country

1

L’Oreal

109

France

2

Elan Pharma International

38

Ireland

3

Nanosystems (ISRA Visions Systems Group)

31

United States

4

Henkel

28

Germany

=5

Cognis Deutschland

15

Germany

=5

Sanofi-Aventis

15

France

7

Amorepacific

14

South Korea

8

Vesifact

13

Switzerland

=9

Japan Science and Technology Agency

11

Japan

=9

GlaxoSmithKline

11

U.Kingdom

11

Rohm and Haas

10

United States

=12

Centre National De La Recherche Scientifique

9

France

=12

Eastman Kodak Company

9

United States

=14

Ciba Specialty Chemical Holdings

8

Switzerland

=14

The Regents of The University of California

8

United States

=16

Diagnostikforschung Institute

7

Germany

=16

University of Texas

7

United States

=18

Alfatec Pharma

6

Germany

=18

Max Planck Gesellschaft

6

Germany

=18

Novartis

6

Switzerland

Of the top 10 pharmaceutical companies on the U.S. market (according to NDCHealth figuresv), Sanofi-Aventis, GlaxoSmithKline, AstraZeneca and Merck have all engaged in nanotechnology patenting. Two further drug giants: Elan Pharma International and Novartis, hold strong patent positions in health-related nanotechnology.

Yet, highlighted by a recent report claiming pharmaceutical giants are investing less money and people in nanotechnology than other industries [16], a number of big pharma companies are noticeably absent from health-related nanotechnology patenting. These include the top pharmaceutical manufacturer in the U.S.: Pfizer, along with Johnson and Johnson, Bristol-Myers Squibb, Abbott Labs and Amgen. Nordon suggests this offers a situation similar to that in biotechnology, “allowing new competitors to take root” [Nordon, cited in 16].

The concern that health-related patents will be ‘locked up’ extends beyond ‘big pharma’ because, with nanotechnology, patents can cross over many industrial sectors [Mooney, cited in 64]. Two of the top 20 institutions with health-related patents (Eastman Kodak and The Regents of the University of California) are also two of the greatest assignees for general nanotechnology patents [8]. Considering that legislative prohibitions, such as the non-patentability of living material, do not stand in the way of nanotechnology, the ETC Group believes that convergence at the nanoscale will become the “operative strategy for corporate control” in 21st century healthcare[63].

In an era when, both within and across countries, health-related decisions are increasingly based upon ‘economic return’ [65], the additional concern is that nanotechnology R&D will be oriented towards the needs of Northern markets [5], thereby exacerbating the 10/90 gapw. For example, though heralded in the literature as an application aimed at a predominantly developing country issuex, Starpharma’s manager of drug development confirmed that their HIV microbicide gel is likely to be aimed at commercialisation on the U.S. and Australian markets by 2010 [McCarthy, cited in, 67]. Such examples provide a good opportunity to more carefully consider suggestions that official development assistance and United Nations’ specialised agency programs assess an incorporation of nanotechnology-based applications [5, 68].

Note:

v.       Available at: http://www.ndchealth.com/press_center/pressreleasearchive.asp.

w.      Whereby, only 10% of spending on health research and development is directed at the health problems of 90% of the world’s people” [66].

x.       See, for example: [5].

Assessing Patents by Utility

Assessing patents by utility, we notice the strong emphasis on therapeutic applications. A large number of patents relate to cosmetic and sunscreen applications, providing initial evidence for Barker et al.’s concern that nanotechnology may be directed at applications most applicable to the North [5]. However, the great majority of therapeutic patents are focussed on new drug delivery mechanisms, already highlighted as an important application for the developing world. Furthermore, a number of applications describe the combining of nanotechnology with traditional medicine for therapeutic benefit. The strength of therapeutically-related patents, compared to diagnostic-related patents challenges Tegart’s suggestion that nanotechnology applications could encourage detection outpacing response capability [2].

Table 6. Categorisation of health-related nanotechnology patents, by utility.

Application

Number of Patents

(%)

Examples

Therapeutic

775

52

Drug delivery mechanisms, vaccines, nutraceuticals, bone scaffolds

Diagnostic

270

18

Sensors, biomarkers

Consumer health

449

30

Cosmetics, sunscreens,  antibacterial/antiseptic/antimicrobial coatings, water purification systems

Patents Classified by Disease

An assessment of all titles and abstracts for cited diseases shows that patenting is strongest for non-communicable diseases (see Figure 5 for a list of the 10 most cited diseases). By citation, cancer is receiving the greatest focus, propelled by funding such as the $144 million committed to nanotechnology cancer research in the U.S. [69]. Yet cancer’s burden, in terms of overall numbers, is greatest in the developing world [70]. Hepatitis is the second most cited disease, yet the majority of patents relate to Hepatitis B which is most prevalent in the developing world [71]. Non-communicable diseases include osteoporosis, beri-beri, stroke and diabetes mellitus. Yet, much of the projected doubling of diabetes mellitus cases by 2025 will stem from increases in developing countries [72]. Influenza, acne, AIDS and vaginitis represent the remaining communicable diseases and are conditions prevalent in both the developed and developing world. Numerous references to various waterborne diseases, staph infections and viruses such as HIV were not included in this research but would have shown HIV/AIDS receiving a greater focus than represented in our disease citation data.

AZoNano - Nanotechnology - The 10 most cited diseases in health-related nanotechnology patent abstracts.

Figure 5. The 10 most cited diseases in health-related nanotechnology patent abstracts.

With a growing recognition that “…health differences between countries will be narrowed” [73], one challenge is to ensure that developed world research into areas such as cancer, hepatitis and AIDS does not limit research into developing country applications. As discovered with ‘Golden Rice’, “when it came time to prepare this new rice for those countries and people for whom it was intended… many of the techniques used by the researchers were patented…”  and these barriers took a great deal of time and effort to overcome [62].

The research shows very little focus on neglected diseases. Two of the worlds greatest killers, malaria and tuberculosis, are noticeably absent from any significant level of nanotechnology patenting. In one respect, this could mean that little research being undertaken in these areas has been transferred to the commercial setting. However, what is more likely is its signifying that these diseases are receiving attention disproportionate to their global impact.

Global Participation Nanotechnology Dialogue

Court et al have suggested that the greatest lesson nanotechnology can learn from biotechnology is that there should be a democratic and more widespread participation in discussions concerning society [4]. To avoid a ‘Genetically Modified Organism-style’ backlash but simultaneously ensure legitimate handling of public concerns, developing country representatives must play a significant part in global nanotechnology discussions.

Forty-three participants from 25 countries gathered in the U.S. for the first intergovernmental dialogue on Responsible Research and Development of Nanotechnology (IDRDN) and 106 participants from 18 countries assembled in Italy for the North-South Dialogue on Nanotechnology: Challenges and Opportunities (NSDN).

Table 7. Breakdown of country representation at the International Dialogue on Responsible Research and Development of Nanotechnology and the North-South Dialogue on Nanotechnology

Developed Countries

Developing & Transitional Countries

Country

IDRDN

NSDN

Country

IDRDN

NSDN

United States

7

10

South Africa

2

5

Italy

1

72

Argentina

1

2

Japan

5

1

India

1

2

United Kingdom

1

3

Mexico

2

 

Taiwan

3

1

South Korea

2

 

Canada

3

 

Brazil

1

1

Australia

1

2

Czech Republic

1

 

France

2

 

Egypt

 

1

Slovenia

 

2

Israel

1

 

Belgium

1

1

Malaysia

 

1

Germany

1

1

Nigeria

 

1

Switzerland

1

1

Romania

1

 

Austria

1

 

Russia

1

 

Ireland

1

 

Uruguay

 

1

The Netherlands

1

 

 

 

 

New Zealand

1

 

 

 

 

Total

30

92

Total

13

14

Both conferences demonstrated a strong presence from the host nation, with Italy contributing 67% of the overall NSDN participants. Developing country representation, in both dialogues, was weak, contributing to 30% of the IDRDN constituency and 13% for the NSDN. Furthermore, in a breakout group at the IDRDN, titled ‘nanotechnology and developing countries’, only 3 of the 13 representatives were from developing countries (Argentina, South Africa and Mexico). Moreover, participants in this group commented that the allocated time for their discussions (less than two hours) was insufficient [42].

China’s Absence from Discussions

Whilst South Africa played a leading role in developing country representation at both events, Chinese delegates were notably absent from both meetingsy. A lack of Chinese engagement in international nanotechnology dialogue weakens efforts to ensure nanotechnology is developed responsibly and for the benefit of those most in need.

Note:

y.       Although a Chinese paper was distributed at the NSDN.

Concerns for Some Developing Nations

With many development groups tending “…to stay away from the emerging nanotechnology debate” [5], there is significant concern that developing country voices will not be heard in the international development of nanotechnology. This was highlighted by a session on nanotechnology held at the 5th World Social Forum in Brazil. Furthermore, representatives from India, Nepal, Sri Lanka, Pakistan and Bangladesh, as signatories of the ‘Dhaka Declaration’, wrote of their concern for the loss of traditional methods and potential health risks associated with nanotechnology [74].

Attempting to Address The Lack of Cohesion in Global Nanotechnology Policy

Some attempts have been made to address the lack of cohesion in global nanotechnology policy. The International Association of Nanotechnology claims to address important global issues such as: nomenclature & terminology; safety; standards; intellectual property; regulation; ethics; society and the environment [75]. The International Council On Nanotechnology (ICON) is the “only global organization aimed at providing… meaningful and organized relationships among diverse stakeholders” [76]. The International Nanotechnology and Society Network “consists of researchers exploring the connections between society and the possible upcoming changes provided by nanotechnology research” [77].Yet all three examples are U.S.-based, posing logistical and, perhaps, political challenges to an incorporation of truly global perspectives. Furthermore, major environmental groups invited to participate in ICON, have protested that the sole funding for the group comes from industrial members [78, 79]. Hence the need for a permanent United Nations’ committee on nanotechnology to ensure debates occur outside the national context but include a truly global range of national perspectives.

Conclusions

Our research has shown a more widespread developing country engagement and interest in nanotechnology R&D than previously documented although this, itself, will not promote a more equitable engagement with global science. Early signs are that developing countries will direct nanotechnology R&D to ‘value-add’ to export markets, rather than use nanotechnology to promote sustainable development. The considerable absence from countries with a low HDI signals that the ‘nano-divide’ is already here and exists just as strongly within the developing world as between the North and South. Although some examples are provided of developing countries inexpensively establishing national nanotechnology programs, one cannot generalise about the cost of nanotechnology innovation. Considerable barriers exist for less-developed countries seeking to engage with nanotechnology R&D on a national level. Some of these barriers are uniform but entry costs will vary from country to country depending on factors such as the selection of research directions.

A number of international nanotechnology partnerships and alliances have been established. At the moment, partnerships look set to promote some of the more industrialised developing countries, leaving behind many of the less-developed countries interested in nanotechnology. The challenge for people in policy circles investigating the engagement of developing countries with nanotechnology is to constantly assess whether their work is helping reduce technological dependency in both hard and soft forms. A combination of regionally- and internationally-facilitated access to resources and information may prove crucial for developing countries geographically isolated from nanotechnology infrastructure and R&D.

Viewing the overall picture of health-related nanotechnology patents, we see that control lies firmly with the industrialised countries of the North, although China is ensuring strong representation from the developing world, relative to its general patent input. The U.S. holds a strong lead in health-related nanotechnology patenting. However, the 2004 data indicates that China is placing pressure on U.S. dominance. Ownership rests firmly with the private sector, following a relatively earlier MNC engagement with nanotechnology than witnessed with biotechnology. The research is primarily oriented towards therapeutic applications, particularly drug delivery mechanisms, with great interest in cancer and hepatitis. Many of the diseases and conditions cited in the patents hold increasing relevance for the developing world although it must not be assumed that such research can, or will, be transferred.

Global participation in the development of nanotechnology policy and directions appears limited to U.S.- and European-led efforts with the notable absence of China from key international meetings. As it is currently placed, nanotechnology is in danger of replicating the inequitable trends of biotechnology with respect international participation in dialogue.

Overall, there are some encouraging signs that certain developing countries could play a significant role in the global development of nanotechnology. Yet, in light of increasing, market-based barriers and limited country participation on a number of levels, early signs are that nanotechnology will promote a greater global technological divide.

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Contact Details

Donald C. Maclurcan

Institute for Nanoscale Technology, University of Technology, Sydney
PO Box 123, Broadway
Sydney, 2006
Australia

Donald.C.Maclurcan@uts.edu.au

 

Date Added: Oct 19, 2005 | Updated: Jun 11, 2013
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