Advantages of SiMPore CytoVu Imaging Slides for Drug Absorption Assays

Topics Covered

CytoVu Imaging Slides
Benefits of Using CytoVu Imaging Slides
Applications for CytoVu
SiMPore

CytoVu Imaging Slides

CytoVu™ imaging slides from SiMPore's are molecularly thin and highly permeable, making them the perfect scaffold for drug absorption assays. At just 50 nm thick and with nanoscale pores, drugs absorbed by a cell can be quickly detected. In contrast, conventional membranes require an absorbed drug to pass through 10 µm of tortuous tunnels before being detected.

Benefits of Using CytoVu Imaging Slides

Advantages of CytoVu™ over conventional membranes for drug absorption assays include:

  • CytoVu membranes are much thinner (1000x), reducing the number of molecules that get trapped in the membrane and improving the signal to noise ratio
  • They are more permeable (100x), allowing more effective diffusion of drugs.
  • CytoVu™ allows cells to be co-cultured at physiological distances, allowing more physiologically relevant absorption models.
  • The transparent nature of CytoVu membranes allows you to be able to image directly on the culture slide at the highest possible quality

Applications for CytoVu

CytoVu™ is perfect for applications such as:

  • Cell Co-Culture
  • Cell Differentiation/Development
  • Microenvironment/Paracrine Signaling
  • Physical Cell-Cell Interactions
  • Migration/Invasion
  • High Quality Imaging
  • Drug Absorption
  • Polarized Cell Growth
  • Tissue Engineering

For more details on the applications and advantages of CytoVu™ products, click here.

SiMPore

SiMPore is a Rochester, New York-based nanotechnology company that designs and produces membranes and membrane-enabled products based on its unique patent-pending platform technology - the UltraSM® ultrathin nanoporous silicon membrane. The UltraSM® membrane is the world’s first membrane to offer both tunable nanometer-scale thickness and pore size. SiMPore is developing products that take advantage of theses one-of-a-kind features, including filters for separating and concentrating biological molecules and nanoparticles, cell culture substrates for growing cells, and electron microscopy grids for preparing and imaging samples at the nanoscale.

This information has been sourced, reviewed and adapted from materials provided by SiMPore.

For more information on this source, please visit SiMPore.

 

Date Added: Apr 12, 2011 | Updated: Jun 11, 2013
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