ForceRobot®300 from JPK Instruments is a fully automated force spectroscope that allows the real-time study of molecular interactions and is built to perfectly address all the demands of a cutting edge force spectroscopy experiment.
Using it overcomes the limitations of traditional force measurements. The automated setup and continuous adjustments provide high efficiency of data collection.
Integration with optical techniques allows targeted measurements at the molecules of interest.
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Key features of the ForceRobot 300 automated force spectroscope include:
- Fully automated force spectroscope with highest flexibility > 80,000 curves per 24 hours
- Cutting edge force spectroscopy and force mapping in combination with single molecule fluorescence
- Advanced and dedicated software with ExperimentPlanner™, RampDesigner™ and built-in data batch processing
- Temperature control 0 – 100 °C and software controlled eight channel fluidics
- Integrates with inverted optical microscopes adding single molecule fluorescence
- Ultra fast force mapping over areas up to 20x20 mm
- Automated laser and detector alignment
- Automated cantilever drift compensation
The ForceRobot 300 automated force spectroscope can be used for:
- Single molecule studies on DNA, RNA, proteins, dendrimers, carbohydrates, lipids etc
- Quantification of kinetics, affinity and molecular mechanisms of biological interactions
- Binding studies such as receptor/ligand or antibody/antigene
- Analysis of protein (un)folding and function
- Mechanical studies on soft materials
- Biochips, biosensors
- Testing functionalized surfaces
- Polymer and thin film mapping in air and liquid with different temperatures or liquids such as non aqueous solvents
- And many more
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Studying how force regulates the structures and conformational dynamics of biomacromolecules.
It was so amazing to get the experiments done automatically without attendance using the ForceRobot®. I saw that this could save a lot of tedious routine manipulation time. I was impressed that the machine can be controlled remotely through internet or smartphone, which means that the operator can leave experiments running when at home or away from the laboratory.
Prof. Yi Cao, Institute of Biophysics, Nanjing University
The ability to measure forces between a pair of interacting biomolecules enables explorations of the molecular basis of disease, and exploring the effects of bacterial DNA binding/remodelling proteins on the mechanical properties of DNA.
Working with the ForceRobot enables my research group to perform more experiments without tying them to the bench to manually adjust parameters between each measurement. The system shows a lot of potential to provide improved statistical data.
Dr Stephanie Allen, Laboratory of Biophysics and Surface Analysis, University of Nottingham
Using single molecule force spectroscopy to study interactions between peptides and proteins involved in the development of these neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.
When the ForceRobot was left running overnight, and I come to work in the morning and find it is about to finish collecting thousands of force curves, I feel really excited because I can look at the data right away.
Prof. Yuri Lyubchenko, University of Nebraska Medical Center
ForceRobot 300® from JPK Instruments
JPK ForceRobot® 300 mounted on an inverted optical microscope
JPK ForceRobot® 300 stand-alone setup