NanoBio Corp. announced
today that data from a large ferret study indicates that its intranasal, nanoemulsion-based
adjuvant elicits robust immunity and cross protection against influenza using
1/15th of the standard antigen dose, without evidence of toxicity or tolerability
concerns. The company also announced that data from a large GLP toxicity study
in rabbits demonstrated similarly robust immune responses without signs of toxicity
or inflammation.
Data from both studies will be presented on Sunday, September 13th at 11:15
am at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy
(ICAAC) at the Moscone Center, San Francisco, CA. The poster references are
as follows:
Poster # G1-877: Intranasal W805EC Adjuvanted Fluzone Provides Robust Immunity
and Cross-Protection in Ferrets
Poster # G1-878: A GLP Toxicity and Immunogenicity Study of NB-1008, an Intranasal
W805EC-Adjuvanted-Fluzone Vaccine
NanoBio will sponsor corporate booth # 1711 at ICAAC, where information on
the company’s development programs for its vaccine, dermatological and
anti-infective programs will be available.
About NanoBio’s Vaccine Platform
NanoBio’s nanoemulsion-based, intranasal vaccines have elicited robust
immune responses in animals vaccinated against seasonal and pandemic influenza,
hepatitis B, RSV, HIV, pneumococcus, anthrax, smallpox and other diseases. The
company’s NanoStat™ adjuvant platform technology has demonstrated
numerous potential advantages over traditional vaccines, including: the ability
to generate robust mucosal, systemic and cellular immunity; antigen sparing
qualities; cross-protection against strains not included in the vaccine; ability
to adjuvant multiple antigen types without inducing inflammation; thermal stability
of the vaccine; and removing the need for needles.
NanoBio Corp. announced earlier in 2009 that the U.S. Food and Drug Administration
(FDA) approved the company’s Investigational New Drug (IND) application
for a Phase 1 clinical study of NB-1008, a seasonal influenza vaccine administered
intranasally. This Phase 1 study is ongoing.
NanoBio® Corp. is a privately held biopharmaceutical company focused on
developing and commercializing dermatological products, anti-infective treatments
and intranasal vaccines derived from its patented NanoStat™ technology
platform. The company’s lead product candidates are treatments for herpes
labialis (cold sores), onychomycosis (nail fungus), acne, cystic fibrosis and
a broad platform of intranasal vaccines. The company’s headquarters and
laboratory facilities are located in Ann Arbor, Michigan.