Optimizing Microfluidic LNP Formulations with In-Line Particle Size and Concentration Measurements

About this Webinar

Confirmation of lipid nanoparticles (LNP) production via microfluidic precipitation under distinct formulation conditions often demands tedious offline analyses of polydispersity and particle size for each prep. In this webinar, an integrated approach to automating microfluidic production and characterization of LNPs with in-line multi-angle light scattering (MALS) and dynamic light scattering (DLS) is described.

Key Points

  • Calypso is an automated, hands-free screening instrument that is highly flexible and accurate and is mixing chip ‘flexible’ if required.
  • The ultraDAWN MALS/DLAS is a well-integrated instrument allowing full control over RNA-LNP production and provides size, particle concentration and polydispersity and size distribution.
  • Calypso meets all the needs of a microfluidic instrument to produce RNA-LNPs

About the Speakers

Jeremie Parot has a PhD in Analytical and Environmental Chemistry from Université de Bordeaux, specializing in nanoparticle metrology. After his PhD, he continued at Université de Bordeaux as a Postdoctoral Researcher, looking at chemical contaminations in the Gironde estuary, before holding another Postdoctoral Research position at the National Institute of Standards and Technology (NIST) in nanoparticle metrology for health.

In 2020, Jeremie joined SINTEG as a Research Scientist, where he works in several research areas, including investigating and generating new intellectual property of novel methods within the lipid nanoparticle space.

Daniel Some has a PhD in Physics from Brown University, has held Postdoctoral positions (Los Alamos National Laboratory and Weizmann Institute of Science), and has experience as a Test and Evaluation Officer for the Israel Defence Forces and as technical staff at Applied Materials.

Since 2004, Daniel has worked at Wyatt Technology – nearly 20 years – where he is currently the Principal Scientist and continues to support Marketing (previously Director). His primary focus is developing and commercializing Wyatt’s process analytical instrumentation.

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