DynaPro® Plate Reader III for Automated Characterization of Size, Stability and Molecular Weight

DynaPro Plate Reader III for Automated Characterization of Size, Stability and Molecular Weight

High-throughput dynamic light scattering helps speed up size and stability screening

High- throughput dynamic light scattering (HT-DLS) and the automated DynaPro® Plate Reader III enable revolutionizing the biotherapeutic and nanoparticle development. The DynaPro excels at high-throughput sizing and screening of nanoparticle and biopharmaceutical formulations to enable novel workflows that would not be possible with other DLS instruments.

The DynaPro® Plate Reader III provides a complete solution in a standard well plate

  • Formulate nanoparticles
  • Optimize protein buffers
  • Discover small-molecule and peptide drugs
  • Develop stable biopharmaceuticals

Achieve the Complete Attribute Landscape

  • Size and size distributions (rh)
  • Molar mass (Mw)
  • Aggregation and stability indicators (Tonset, Tagg, Tm, A2, kD)
  • Solubility
  • Viscosity

Fast, Easy, Accurate

  • Sample volume as low as 4 μL
  • As sensitive as a cuvette-based DLS
  • Film- or oil-based evaporation seal
  • Measure from 4º to 85 ºC
  • 21 CFR Part 11 compliant software
  • First and only A2 and Mw in a plate
  • Infrared wavelength not susceptible to fluorescence
  • User friendly experiment design in Dynamics
  • Uses industry-standard 96, 384 or 1,536 microwell plates

Design High-throughput Experiments

Advantages

Content-rich screening data can be explored and comprehensive DLS experiments can be tackled like never before.

Weeks of Experiments within Just Hours

Biologics: Thermal and Colloidal Stability

The DynaPro Plate Reader III carries out high-throughput screening of biotherapeutic candidates, in order to determine multiple properties of a plateful of candidates and formulations. On the right is the analysis of monoclonal antibodies (mAbs) for thermal stability.

 

 

 

 

 

 

 

 

 

 

 

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