DynaPro NanoStar II Dynamic Light Scattering Detector

The DynaPro® NanoStar®  II is a cuvette-based dynamic light scattering (DLS) instrument used for the analysis of the size and size distributions of peptides, proteins, polymers, nanoparticles and emulsions. A separate, optimized static light scattering (SLS) channel offers true molar mass measurements.

The NanoStar II is among the most sensitive, robust and reliable DLS detectors available for protein and nanoparticle analysis.



  • Sensitivity: 0.1 mg/mL of 14.4 kDa lysozyme in PBS
  • Molar mass range: 300 Da to 1 MDa
  • Particle Concentration Range: 1x10to 1x1015 mL-1 (dependent on size)
  • Size Range Rby DLS: 0.2 to 1000 nm

Temperature Range

  • -10°C to +120°C (0°C to 80°C with disposable cuvettes)
  • Maximum ramp rate 15°C/min
  • Stability: ± 0.01°C

Sample Options - Sample Cells

  • Quartz 2 µL or 45 µL cuvettes
  • Disposable 4 µL cuvette (cyclic olefin copolymer)
  • Generic 4 mL quartz and disposable cuvettes (with adapter)

Sample Options - Minimum Sample Volume

  • 2 µL in quartz cuvette
  • 4 µL in disposable cuvette


  • Laser Wavelength: 658 nm
  • Laser Power Control: Programmable 10% to 100%
  • Scattering Angle: 90º
  • Optical Fiber: Multi-mode
  • Additional Detectors: Laser monitor for active stabilization
  • Additional Detectors: Forward monitor measures transmitted light for turbidance and laser/cell diagnostics


  • Data Acquisistion Time: 1 to 3600 sec
  • Correlator: 512 channel, 100 nsec sampling time in a multi-tau layout


  • 57 cm (L) x 36 cm (W) x 20 cm (H) 


  • Size, aggregation and stability of small molecules, peptides, proteins, vesicles, nanoparticles, quantum dots and low/sub-micron colloids
  • Protein quality control for interaction or structural studies
  • Protein and polymer weight-average molecular weight
  • Macromolecular interactions: diffusion interaction parameter kD and second virial coefficient A2 (B22)
  • Thermal onset parameters Tagg, Tonset, Tm
  • Solubility of polymers
  • Critical micelle concentration and temperature
  • Nanoparticle structure by combining MALS and DLS sizing

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