:: AZoNanotechnology Article
Designed to Meet Your Needs
Capillary Zeta Potential Cell
The new Zetasizer Nano ZS brings you the practicality of a
maintenance-free system with the versatility to offer precision measurement for
your laboratory's particle characterization needs.
Figure 1. The Malvern Zetasizer
Non-invasive back scatter (NIBSR) technology takes particle sizing to new
levels of sensitivity in the 0.6nm to 6 micron range. The new Zetasizer Nano ZS is the choice for accurate, reliable and
repeatable size analysis including protein melting point determination.
- Proteins and polymer analysis
- Little or no dilution necessary
The new Zetasizer Nano ZS offers the highest ever sensitivity, accuracy
and resolution of zeta potential. This is achieved by a combination of laser
Doppler velocimetry and phase analysis light scattering (PALS) in Malvern's patented M3-PALS technique. Even samples of very low
mobility can be analyzed and their mobility distributions calculated.
- Emulsion stability
- Formulation stability
- Water treatment
- Pigment performance
- Impurity determination
Using static light scattering (SLS) and the classical Debye plot, the
molecular weight of random coiled polymers up to 5 x 105 Da as well as globular
polymers and proteins up to 2 x 107 Da can be determined without the
necessity for multi-angle measurement.
- Protein and polymer characteristics
- Protein crystal screening
- 2nd virial coefficient determination
- Micelle structure
- Protein-ligand binding
Operating features of the Zetasizer Nano ZS that make it user friendly include:
- Unique maintenance-free zeta potential cell
- No alignment, calibration or maintenance required
- Zeta potential and size can be measured in the same cell
- Automatic cell recognition system
The operation of the Zetasizer Nano ZS involves 5 simple steps:
- Power up the Zetasizer Nano ZS and launch the software - An automatic
complete system self-check ensures that all components are ready for operation.
- Fill the maintenance-free cell - The amazing low volume, folded capillary
cell is the first ever for zeta potential which does not require cleaning. To
eliminate cross-contamination, fill it, measure and, instead of cleaning, use a
- Load the cell - Simply insert the cell with its integral gold electrodes,
close the lid and it's ready to go.
- Run the measurement - From the menu, select the standard operating procedure
(SOP) you need or set your own conditions and click the 'start' button.
- View the results - Predefined reports make reading, comparing and analyzing
the results straightforward.
Remove the maintenance-free cell and you are ready to go again.
Designed to Meet Your Needs
At Malvern we strive for improvement in every instrument we
design and produce. This process is made possible because we continually ask our
customers what they think and what they need before turning those wishes into
Standard Operating Procedures (SOPs) The use of SOPs ensures
that measurements can be repeated using exactly the same parameters to give
confidence in the result.
Low volume sample measurement (for valuable proteins and
A comprehensive range of low volume cells and a unique low
Size measurement at low concentrations
NIBSR (non-invasive back scatter) technology built in for
increased particle sizing sensitivity and to make it possible to characterize
proteins and polymers <1nm in size and with molecular weights as low as
Simplified sample preparation - especially for emulsions
Instruments which can analyze samples with little or no
Elimination of sample cross contamination and no need to clean
cell or electrodes
Unique maintenance-free folded capillary cell. The world's first
disposable zeta potential capillary cell
Ability to measure zeta potential in high salt systems and
Patented M3-PALS (phase analysis light scattering) technology
which allows operators to improve resolution as well as automating the process
Compliance with regulatory standards
Compatibility with 21 CFR part 11 and all other current
Unique Folded Capillary Zeta Potential Cell
Introducing the unique patented folded capillary zeta potential cell
- First ever maintenance-free zeta potential cell. Simply use it for a single
sample or series of experiments then, instead of cleaning it, use a new cell.
- Gold electrodes for widest range of sample compatibility
- Compact design for low volumes down to just 0.75ml.
- Consistent and stable field held at measurement point
Figure 2. The capillary zeta potential cell for the
The Zetasizer Nano ZS also accepts the re-usable dip cell which is
required for non-aqueous applications - it can also be used for samples
dispersed in aqueous media.
Automated titration and sample preparation with the MPT-2 Autotitrator
While zeta potential alone is often used to make comparisons between
materials and formulations, measuring zeta potential as a function of pH,
conductivity or concentration of an additive, provides much greater insight into
the processes involved in stabilizing or flocculating disperse systems.
Figure 3. The MPT-2 autotitrator for the Malvern
Using the MPT-2 autotitrator these measurements can be made automatically
using samples of less than 3ml, which allows comprehensive analysis of even
scarce biological materials.
Operation is fully automated and protocols can be specified as part of
standard operating procedures.
For more information on this source please visit Malvern Instruments
Ltd (UK) or Malvern Instruments