Posted in | Nanomaterials

Discover PCL Nanoparticles from Merck

In the development of particulate drug delivery systems, biodegradable polymers with strong biocompatibilities, such as poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and polycaprolactone (PCL), have been frequently employed.

For particular drug delivery applications like sustained release, targeted drug delivery, and protecting APIs from premature degradation, active pharmaceutical ingredients (APIs), whether small molecules or biologic compounds, can be encapsulated into microspheres and nanoparticles or attached to a particle’s surface.

After administering drug-loaded biodegradable nanoparticles and microparticles, the biocompatible polymer undergoes in vivo degradation through hydrolysis of the ester backbone, forming non-toxic products. Choosing the appropriate polymer type and modifying the encapsulation procedure will control the drug release rate.

Poly(Ɛ-caprolactone) is used to make PCL particles, which have a molecular weight of 14,000 mg/ml when suspended in dimethyl ether. Before each use, sonicate or vortex the particles.


Source: Merck

. .
PCL Nanoparticles 100 nm average diameter
PCL Nanoparticles 1 μm average diameter
PCL Nanoparticles 10 μm average diameter
PCL Nanoparticles 200 μm average diameter
PCL Nanoparticles 2 μm average diameter
PCL Nanoparticles 500 nm average diameter
PCL Nanoparticles 5 μm average diameter

Other Equipment by this Supplier

Azthena logo powered by Azthena AI

Your AI Assistant finding answers from trusted AZoM content

Your AI Powered Scientific Assistant

Hi, I'm Azthena, you can trust me to find commercial scientific answers from

A few things you need to know before we start. Please read and accept to continue.

  • Use of “Azthena” is subject to the terms and conditions of use as set out by OpenAI.
  • Content provided on any AZoNetwork sites are subject to the site Terms & Conditions and Privacy Policy.
  • Large Language Models can make mistakes. Consider checking important information.

Great. Ask your question.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.