Malvern
Instruments will demonstrate a new application for foreign particle determination
on filters, and will show new systems for protein characterization and rheology
measurement at the 2008 AAPS Annual Meeting & Exposition (17-20 Nov, Atlanta,
USA). Foreign particulate matter determination on the Morphologi G3, the Zetasizer
APS and Zetasizer µV systems for protein characterization in pharmaceutical
and biotechnology applications, and the radical new Kinexus rheometer platform
have all been launched since the beginning of September. This is one of the
first events at which they are being exhibited.
As well as supporting the exhibition, Malvern is participating in the conference.
Dr Paul Kippax, product manager for laser diffraction systems at Malvern, will
contribute a paper on ‘Method Development and Validation for Particle
Size Measurements’. His presentation will examine requirements for the
development and validation of particle sizing methods, with reference the FDA’s
guidance documentation, the US pharmacopoeia and the available international
standards.
Morphologi G3 : Foreign particulate matter – detection, enumeration,
size classification
A new capability on Malvern’s award-winning Morphologi G3 automated particle
characterization system enables the fully automated detection, enumeration and
size classification of foreign particulate matter (FPM) collected on a filter.
In the pharmaceutical industry this is especially important in controlling particulate
contamination of materials for injection or inhalation. Analysis of FPM on filters
has traditionally been the preserve of manual light microscopy. Now, the Morphologi
G3 brings fully automated image analysis to accelerate characterization and
remove any operator subjectivity.
Zetasizer APS: Protein characterization in microplates
The Zetasizer APS is a new dynamic light scattering (DLS) system which automates
size measurements of samples in 96- or 384-well microplates. Designed primarily
for protein specialists, it is fully automated, simply requiring users to insert
the plate and press start. The Zetasizer APS allows quick and easy investigation
of a protein’s condition at different stages of the purification process,
and at later stages of formulation under a range of environmental conditions.
The measurement technology used delivers results with exactly the same high
precision and reproducibility you would expect from a research grade batch DLS
system. www.malvern.com/zetasizerAPS
Zetasizer µV: Requires just 2 microlitres for biomolecule characterization
The new Zetasizer µV is an advanced light scattering system specifically
intended for the characterization of proteins and other biomolecules. Designed
and optimized for maximum sensitivity and minimum sample volume, the Zetasizer
µV is a dedicated system that supports improved understanding and management
of a wide range of biomolecule applications, including: optimizing sample and
storage conditions; verifying the quaternary structure of protein complexes;
identifying thermal characteristics; and assessing protein solubility and sample
purity. www.malvern.com/zetasizerMicroV
The new Kinexus – more rheology, less effort
Kinexus is the radical new rotational rheometer platform from Malvern Instruments.
Completely redefining the rheometer, Kinexus enables users to spend less time
learning how to interact with their system and more time investigating ways
to characterize and enhance a material's performance. Embedding expert knowledge
and adaptive intelligence within the instrument delivers application-relevant
and high quality data for all users, generating information that will truly
add value to a product or process. www.malvern.com/kinexus