NanoSight Pro for Characterizing Nano- and Biomaterials

NanoSight Pro is Malvern Panalytical's best-in-class, simple, quick and accurate nanoparticle tracking analysis (NTA) solution for nano- and biomaterials characterization.

The combination of advanced engineering and a blend of smart features means that NTA measurements are rapid, efficient, and accessible to all users. Machine learning-powered NS Xplorer software prevents subjectivity, automates measurements, and provides the highest quality size and concentration data for fluorescence and light scatter analysis.

Interchangeable lasers provide application flexibility, while Smart Manager connectivity ensures robustness without having to worry about downtime or quality issues. 

NanoSight Pro for Characterizing Nano- and Biomaterials

Image Credit: Malvern Panalytical

NanoSight Pro for Characterizing Nano- and Biomaterials

Image Credit: Malvern Panalytical

NanoSight Pro for Characterizing Nano- and Biomaterials

Image Credit: Malvern Panalytical

Overview

The software interface is logical and user friendly, even for a first-time user.

Rebecca Dragovic, Teaching Fellow & Research Scientist, Nuffield Department of Women’s & Reproductive Health, University of Oxford

NanoSight Pro: Expert Nanoparticle Tracking Analysis

Video Credit: Malvern Panalytical

Features and Benefits

Quick Install and Analysis

Any user in any lab can use NanoSight Pro. The smart installation allows users to get up and running quickly. Users can evaluate their samples in just a matter of minutes with minimal setup, simple operation, and intuitive NS Xplorer software.

Intelligent and Automated

NanoSight Pro, which is powered by machine learning and intelligent features, automates the processing and removes human error, giving superior particle identification and accurate particle tracking for the highest quality, reproducible data.

Highest Resolution

The NanoSight Pro detects nanoscale particles in the range of 10 nm to 1000 nm in size, including low scattering and biological particles. Particle–by–particle analysis ensures concentrated, high-resolution data with visual confirmation.

Power of Fluorescence

Fluorescence signals can be recognized from fluorescently tagged biologics or synthetic particles, offering greater insight into the sample. Interchangeable laser modules with four excitation wavelengths and corresponding long-pass filters can be utilized for the best setup accompanied by in-flow analysis for improved sampling and tracking of even photobleaching materials.

Increased fluorescence sensitivity facilitates subpopulation identification, including surface markers, internal cargo detection, and contaminant sensitivity depreciation.

What Customers Think

It is the easiest bit of equipment I have ever installed in the lab

Oliver Huseyin, Research Scientist, MIP Diagnostics Limited

Key Applications

The Malvern Panalytical NanoSight Pro has numerous applications, including:

Extracellular Vesicles (EV)

While the investigation into the generation and functions of extracellular vesicles is still progressing, monitoring and controlling their isolation and purification is essential.

The NanoSight NTA enables the quick and easy evaluation of vesicle size and concentration in aqueous buffers, giving users confidence in the quality of the sample utilized in any downstream research, while fluorescence can aid in clarifying the origin subpopulations of EVs.

Virus and Vaccines

Controlled production processes are essential when manufacturing vaccines to guarantee that the immune system can dose and recognize the materials appropriately. NTA is a great way to optimize your manufacturing processes as it ensures the size distribution of the vaccine is maintained. As NTA is also able to count and size viruses, it can be used as a quicker alternative to titer assays.

Drug Delivery and Gene Therapy

When it comes to drug delivery and gene therapy products, 70–150 nm is the standard size of particles needed to guarantee efficient disease targeting in the clinical. NTA is well adapted to studying the size of these particles from early-stage research through candidate screening, formulation development, and clinical batch monitoring, while concentration measurement enables final product dose calculation as well as usage in both in vitro and in vivo assays.

Biotherapeutics

Temperature, pH change, agitation, shear, and time all have an effect on the stability of biotherapeutic proteins, inducing denaturation and aggregation, which can lead to efficacy loss and the possibility of an undesirable immune response. For safety and quality assurance, NTA delivers high-resolution size distributions of sub-visible aggregates in a formulation.

Nanomaterials/Colloids/Toxicology

Nanomaterials are becoming a topic of interest for regulatory bodies as they are being incorporated more and more into everyday items. As such, it is necessary to completely characterize these particles, their properties, and their contribution to the final product. For individuals working at the nanoscale in industrial, environmental, and toxicological domains, NanoSight can give a number-based concentration for these nanomaterials as well as high-resolution size distributions.

Ultrafine Bubbles

Ultrafine bubbles have also become a popular topic in recent years. These bubbles find applications in industrial cleaning and water treatment, agriculture and food, and medical applications. Despite their relatively low concentration and small size being a challenge for many traditional nanoparticle characterization techniques, NTA is particularly well-suited for detecting and analyzing these bubbles.

Specification

General

Table 1. Source: Malvern Panalytical

. .
Technology Nanoparticle Tracking Analysis
Size range (diameter) 1 10 nm - 1000 nm
Particle concentration 2 106 to 109 particles / mL
Minimum sample volume 250 μL
Advanced Concentration Algorithm Concentration Upgrade

System

Table 2. Source: Malvern Panalytical

. .
Product Compliance Product Laser Class 1 (BS EN 60825-1:2014)
EMC Directive (EN IEC61326-1:2021)
Low Voltage Directive (IEC 61010-1:2010
IEC 61010-1:2010/AMD 1:2016)
Camera High sensitivity sCMOS (USB-3)
Laser information Beam wavelength (maximum power output):
405 nm, max power <70 mW
488 nm, max power <55 mW (blue)
532 nm, max power <60 mW (green)
642 nm, max power <50 mW (red)
Temperature control range 5 °C below ambient up to 70 °C
Temperature readout Automatic
Syringe pump Continuous sample flow with 1 mL syringes
Dimensions (W, D, H) 34x35x25 cm
Weight of instrument 11 kg
Weight of laser module 1.6 kg
Power requirements AC 110-240 V, 50-60 Hz, 4.0 A
Ambient operating conditions Up to 80% rH at 31 °C then decreasing linearly to 50% at 40 °C

Additional Options

Table 3. Source: Malvern Panalytical

. .
Fluorescence – automatic selection 3 For up to 5 filters

Dependent on sample and instrument configuration
Sample dependent
Optional functionality. Long-pass filters available for each laser wavelength

Support

With Malvern Panalytical’s service plans, users can protect their investments and ensure optimal performance at all times.

When acquiring a Malvern Panalytical product, customers are also founding a long-term working relationship, as Malvern Panalytical will always be on hand to support the business based on its needs.

Help Desk

  • Telephone and email support.
  • Operators take responsibility for the call and make sure that the query is answered.

Training

  • User training events

Software Downloads

  • A straightforward method for receiving updates and new features.

Malvern Panalytical’s Service Options—Choose the Right Plan

Malvern Panalytical Platinum Plan

Best suited to laboratories where instrument uptime is vital to daily performance. The highest level of responsiveness and “all-inclusive” plan covers any unforeseen repair fees that may arise.

Malvern Panalytical Gold Plan

Optimizing instrument efficiency will help users increase laboratory efficiency. The company will continue providing priority response and specialized technical and software support to keep the instrument on track to deliver.

Malvern Panalytical Bronze Visit

Regular preventative maintenance is vital for laboratories wanting to improve instrument performance.

Table 4. Source: Malvern Panalytical 

  Platinum Plan Gold Plan Bronze Visit
Annual PM/PV Test
yes
yes
no
Telephone / Email Support
yes
yes
no
Priority Response
yes
yes
no
Emergency Breakdown visits*
yes
yes
no
Parts Included
yes
no
no
Technical & Software Support
yes
yes
yes
IQ/OQ (Pharma)***
yes
yes
yes

*including labor & travel costs  ***available at an additional cost

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