Liposomes have grown as an important biomedical carrier system. One of the most critical factors influencing the performance of liposome is particle size. High-pressure homogenization, extrusion and sonication are methods for reducing liposome size. The extrusion technique is a reasonably mild and quick procedure among them.
![](https://d1otjdv2bf0507.cloudfront.net/images/equipments/EquipmentImage_1986_1649429018398140.png)
Liposome with double layer of phospholipid molecules. Image credits: Genizer LLC
The Genizer Jacketed Liposome Extruder utilizes a nitrogen gas cylinder to force a drug, protein or gene liposome suspension via a track-etched membrane with a predetermined pore size; generally, 5–10 passes are enough to create a sample with consistent liposome size. The Genizer Jacketed Liposome Extruders are designed to produce uniform unilamellar liposomes and lipopolyplexes with minimal dead volume.
![Genizer Jacketed Liposome Extruder for Liposome Size Reduction.](https://d1otjdv2bf0507.cloudfront.net/images/equipments/EquipmentImage_1986_1648277115431975.png)
Genizer Jacketed Liposome Extruder for Liposome Size Reduction. Image Credit: Genizer LLC
Features
- Capacity level of the extruder barrel: 10 mL/100 mL/800 mL/3000 mL
- Filter diameter: 25 mm for GJE10 mL, 47 mm for GJE100 mL, 90 mm for GJE800 mL, 142 mm for GJE3000 mL
- Cooling: jacketed thermo barrel
- Material: 316L stainless steel, NBR or Viton
- Spares: O-rings, collection silicone tubing
- Additional features: Large pore support screen, laser micro pore disc, high pressure nitrogen tubing G5/8