MAPS technology provides the highest resolution, while Litesizer DLS offers the optimum particle sizing with automated angle selection to avoid errors. Measurement reliability is increased by continuous transmittance monitoring, which identifies sedimentation and agglomeration during measurement.
By addressing aging effects and reducing the electrical gradient, cmPALS and Omega Cuvette, exclusive to the system, increase zeta potential accuracy and repeatability.
Litesizer DLS also provides fluorescence and polarization filters for particle concentration measurements in single-angle and three-angle MAPS modes, as well as particle size measurements.
Litesizer DLS 101
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- Size range of particles: 0.3 nm to 10 µm
- An affordable entry to dynamic light scattering
- DLS backscatter detection enables a broad sample coverage
- Transmittance measurement to live-monitor sample behavior
Litesizer DLS 501
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- Particle sizing from 0.3 nm to 15 µm
- Advanced dynamic scattering of light at three angles of measurement
- Zeta potential determination with patented cmPALS
- Molecular mass and refractive index measurements
- Fluorescent and polarization filters for all angles
Litesizer DLS 701
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- Particle sizing from 0.3 nm to 15 µm
- An advanced dynamic light scattering device with all modes
- Fluorescence and polarization filters for all angles
- High resolution via multi-angle particle sizing (MAPS)
- Determination of concentration for up to three size classes
Key Features
Three Angles, Real-Time Monitoring for Better Sizing
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Litesizer DLS provides three alternative detection angles for measuring a wide range of samples while eliminating mistakes with automatic angle selection.
The Multi-Angle Particle Sizing (MAPS) measurement mode provides excellent resolution, enabling advanced analytical precision.
The continuous transmission monitoring is unique in the market since it gives live feedback on sample behavior during the test, giving users quick information on sedimentation or agglomeration. This real-time insight improves measurement quality and reliability, making the system the best choice for precise and consistent particle analysis.
Market-Leading Zeta Potential Analysis
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The dynamic light scattering instrument’s proprietary cmPALS technology is specifically developed to avoid reproducibility errors caused by aging.
The Omega Cuvette’s revolutionary design reduces gradient in the electrical field, improving reproducibility (±3 %). The instrument provides the greatest particle size range for zeta potential measurement, ranging from 1.3 nm to 100 µm. This ensures precise and reliable findings across a wide variety of applications.
Kalliope: The Benchmark Software for Particle Sizing
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The Kalliope software requires minimal user training.
Measurements can be completed in only three clicks. The one-page layout gives a fast overview of input parameters, measurement signals, and outcomes, allowing users to see everything at a glance. Predefined standard reports and categorized result summaries make it easy to retrieve measurement findings.
For additional in-depth research, use the customized report templates, Excel export options, and advanced analysis features. Furthermore, Kalliope is completely compliant with 21 CFR Part 11, assuring strong data integrity and regulatory conformity.
All the Measuring Modes Users Need
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Enhance the adaptability with the Litesizer DLS 701's particle concentration measurement mode, which allows for calibration-free concentration analysis of up to three different size populations inside a single sample. This mode accommodates both monodisperse and polydisperse samples over a wide concentration range, compatible with either single-angle DLS or MAPS measurements.
Users can measure the refractive index of solvents at the same wavelength and temperature as the measurements (European Patent 3 023 770) to ensure optimal accuracy for particle size and zeta potential data. The Litesizer DLS 701 and DLS 501 give accurate refractive index readings within ±0.5 %.
To top it off, the Litesizer DLS series includes molecular mass measurement.
Most Capable Filtering Options Available
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The Litesizer DLS 701 and 501 are the only dynamic light scattering instruments on the market that provide users with a unique choice of fluorescence and polarization filters that can be applied in all three angles.
This allows for particle concentration analysis and MAPS three-angle or chosen single-angle analysis with filters, allowing for different types of studies that are not achievable with comparable equipment (for example, quantum dot concentration determination).
Specifications
Source: Anton Paar GmbH
| |
Litesizer
DLS 701 |
Litesizer
DLS 501 |
Litesizer
DLS 101 |
| Particle size specifications |
| Measurement principle |
Dynamic Light Scattering (DLS) |
| Measuring range |
0.3 nm to 15 μm*
(particle diameter) |
0.3 nm to 10 μm*
(particle diameter) |
| Measurement angles |
15°, 90°, 175°, Multi-angle particle sizing (MAPS) |
15°, 90°, 175° |
175° |
| Min. concentration |
0.1 mg/mL (lysozyme)
lower than 0.00001 % (0.1 ppm, Latex 100 nm) |
0.1 mg/mL (lysozyme) |
| Max. concentration |
50 % w/v (sample-dependent) |
| Min. sample volume |
1.5 µL |
12 µL |
| Accuracy |
Better than +/-2 % on NIST traceable standards |
| Repeatability |
Better than +/-2 % on NIST traceable standards |
| Particle Concentration Specifications |
| Analysis model |
Mie Theory |
- |
- |
| Measuring range |
108 - 1013 particles/mL (sample dependent) |
- |
- |
| Size limit |
1 µm |
- |
- |
| Measurement angles |
15°, 90°, 175°, Multi-angle particle sizing (MAPS) |
- |
- |
| Min. sample volume |
12 µL |
- |
- |
| Accuracy |
+/- 10 % (sample dependent) |
- |
- |
| Repeatability |
+/- 5 % (sample dependent) |
- |
- |
| Zeta potential specifications |
| Measuring principle |
Electrophoretic Light Scattering (ELS) / cmPALS |
- |
| Measuring range |
>= +/-1000 mV |
- |
| Mobility range |
10-11 m²/V.s to 2 x 10-7 m²/V.s |
- |
| Size range |
1.3 nm to 100 µm (diameter) |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Max. sample concentration |
70 %w/v (sample-dependent) |
- |
| Max. sample conductivity |
200 mS/cm |
- |
| Min. sample volume |
50 µL (sample-viscosity-dependent) |
- |
| Accuracy |
Better than +/-10 % |
- |
| Repeatability |
+/-3 % |
- |
| Molecular mass specifications |
| Measuring principle |
Static Light Scattering (SLS) |
- |
| Measuring range (mass) |
300 Da to 20 MDa |
- |
| Measuring range (particle size) |
Up to 40 nm (diameter) |
- |
| Measurement angle |
90° |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Accuracy |
+/-10 % |
- |
| Repeatability |
+/-5 % |
- |
| Transmittance specifications |
| Measuring range |
0 % to 100 % |
| Min. sample volume |
1.5 µL |
15 µL |
| Accuracy |
Better than +/-1 % |
| Refractive index specifications |
| Measuring range |
1.28 to 1.50 |
- |
| Min. sample volume |
1 mL |
- |
| Accuracy |
+/-0.5 % |
- |
| General specifications |
| Light source |
Semiconductor laser diode / 40 mW, 658 nm |
| Optical filters (fluorescence, vertical and horizontal polarization) |
Forward, side and backscattering |
- |
| Laser warm-up time |
6 min |
| Temperature control range |
0 °C to 120 °C |
| Ambient operating temperature |
10 °C to 35 °C |
| Humidity |
Up to 80 % non-condensing |
| Dimensions (W, D, H) |
450 mm, 505 mm, 135 mm |
| Weight |
Approx. 18 kg (40 lb) |
Approx. 16.3 kg (36 lb) |
The Next-Generation Particle Analyzer: Litesizer DLS | Anton Paar
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