Jan 20 2021
Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.
Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation.
The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues.
Clinical trials and preclinical studies using the developed ultra-small nanomedicines are proceeding for cancer therapy.
Published in the website of Journal of Controlled Release on January 6.
https://doi.org/10.1016/j.jconrel.2021.01.001
Source: https://iconm.kawasaki-net.ne.jp/en/