Posted in | News | Nanomedicine | Nanomaterials

Persistently Bright Nanoparticle Images Tumors

In a new take on use of luminescent nanoparticles as cancer imaging probes, a team of investigators from several research institutes in Paris, France, has developed new metal-containing nanoparticles that emit light for several hours after they are initially excited. The researchers have demonstrated that once these nanoparticles are excited, they can then be injected into an animal and imaged without any additional energy input.

Reporting their work in the Proceedings of the National Academy of Sciences of the United States of America, Daniel Scherman, Ph.D., Quentin le Masne de Chermont, Ph.D., and colleagues describe their methods for synthesizing inorganic magnesium silicate-based nanoparticles doped with luminescent metals such as europium and dysprosium along with atoms of manganese. The particles range in diameter from 50 to 100 nanometers. Characterization experiments showed that the luminescent metal atoms concentrate in the center of the resulting nanoparticles together with the manganese atoms, forming an electronic core that can absorb light energy and emit red to near-infrared light for prolonged periods of time.

The investigators also developed chemical methods for modifying the surfaces of these nanoparticles. For this set of experiments, the investigators prepared nanoparticles whose surfaces were either positively charged, negatively charged, or had a neutral charge. They then energized the particles, injected the particles into animals, and monitored their distribution throughout the body in real time using near-infrared spectroscopic imaging. The investigators also used their persistently luminescent nanoparticles to image the new blood vessels surrounding tumors implanted in mice.

This work is detailed in the paper "Nanoprobes with near-infrared persistent luminescence for in vivo imaging." An abstract of this paper is available through PubMed. View abstract.

http://nano.cancer.gov

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type
Submit
Azthena logo

AZoM.com powered by Azthena AI

Your AI Assistant finding answers from trusted AZoM content

Your AI Powered Scientific Assistant

Hi, I'm Azthena, you can trust me to find commercial scientific answers from AZoNetwork.com.

A few things you need to know before we start. Please read and accept to continue.

  • Use of “Azthena” is subject to the terms and conditions of use as set out by OpenAI.
  • Content provided on any AZoNetwork sites are subject to the site Terms & Conditions and Privacy Policy.
  • Large Language Models can make mistakes. Consider checking important information.

Great. Ask your question.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.