Creating better-performing materials comes down to having more control over their structure at the smallest possible scale.
Researchers created iSOD, a superoxide dismutase-templated ultrasmall iron oxide nanozyme that combines antioxidant activity with MRI contrast for liver fibrosis. In rat models, iSOD reduced collagen deposition and produced fibrosis-associated MRI signal differences, although larger studies and quantitative imaging validation are still needed.
Researchers developed a carboxymethyl cellulose-based immunonanosystem containing cobalt-substituted magnetite nanoparticles and anti-CD44 antibodies to target glioblastoma cells through enzyodynamic ferroptosis and photothermal therapy. In 2D cell cultures and 3D gliomaspheres, the system showed preferential activity against CD44-expressing glioblastoma cells, supporting further preclinical studies of its safety, delivery, and therapeutic performance.
PI’s new 6-DOF MagLev linear, rotary and AFM stages deliver contact-free, nanometer-stable motion for hybrid bonding, wafer inspection and metrology.
Researchers showed that point-defect engineering can control how copper nanoparticles exsolve from perovskite oxides, influencing exsolution yield, particle size, nucleation density, and anchoring. The study also found that oxygen vacancies are consumed during exsolution and that lattice strain can eventually limit further nanoparticle formation.
Researchers developed NMm@MINO, a minocycline-loaded gelatin nanoparticle coated with hybrid neutrophil–macrophage membranes to tackle bacterial infection, inflammation, and periodontal tissue damage. In laboratory and rat experiments, the platform killed bacteria, altered inflammatory responses, promoted osteogenesis-associated processes, suppressed osteoclast activity, and reduced alveolar bone loss.
Researchers used spark plasma sintering technology to deposit silver, zinc, and copper metal oxide nanoparticles directly onto thermoplastic starch/carboxymethyl cellulose films, then measured changes in mechanical strength, wettability, morphology, color, and thermal behavior. The treatment increased tensile strength and reduced surface wettability, with the results varying by metal and reflecting interactions between the deposited particles and polymer functional groups.
Researchers developed diimmonium DB·2X nano-agents that support photoacoustic imaging at 1700 nm, with DB·2TFSI showing strong performance in preclinical imaging experiments. In mouse models, 1700 nm imaging reduced endogenous background interference and improved signal-to-background ratios compared with 1064 nm, supporting further investigation of NIR-IIb photoacoustic contrast agents.
Researchers developed a rapid, one-pot method that used sunlight and a commercial vincristine formulation to form gold nanoparticles within five minutes without separate reducing or stabilizing agents. The particles retained vincristine’s antiproliferative activity against Colo-205 colon cancer cells and showed greater DPPH radical scavenging than free vincristine at several tested concentrations, while questions about drug photostability, release, stability, and in vivo performance remain.
Researchers engineered hybrid strontium sulfite nanoparticle-modified lipid nanoparticles to deliver p53 mRNA, producing higher reporter-gene expression, higher p53 transcript levels, and greater apoptosis in breast cancer cells than conventional LNPs. In mice, the p53 mRNA-loaded hybrid carrier slowed 4T1 tumor growth, although the study was small and preclinical, and the clearest biodistribution advantage appeared after PEGylation.
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